阿乐对急性脑梗死患者颈动脉粥样硬化斑块的远期效果观察

Long-term Effect of Atovastatin Calcium on Carotid Atherosclerosis Plaque in Patients with Acute Cerebral Infarction

目的:探讨阿乐对急性脑梗死患者颈动脉粥样硬化斑块的远期效果。方法:选择本院收治的100例急性脑梗死患者作为研究对象,随机分为试验组和对照组。对照组患者采用常规治疗,试验组患者在此基础上采用阿乐治疗,比较两组患者治疗前后TC、TG、LDL、HDL、hs-CRP、斑块面积、IMT和不良反应发生情况。结果:治疗12个月后,试验组患者TC、TG、LDL、HDL和hs-CRP均优于对照组,差异有统计学意义(P<0.05)。试验组患者斑块面积和IMT均低于对照组患者,差异有统计学意义(P<0.05)。两组患者不良反应发生率比较差异有统计学意义(字2=1.375,P<0.05)。结论:阿乐可有效改善急性脑梗死患者血脂水平,减轻患者炎症反应,对颈动脉粥样硬化斑块有着稳定及促进消融作用。

Objective：To evaluate the long-term effect of atovastatin calcium on carotid atherosclerosis plaque in patients with acute cerebral infarction.Method：100 cases of patients in our hospital were chosen as the experimental objects.,and were divided into experimental group and control group,control group were treated with routine treatment,and the experimental group were treated with atovastatin calcium on the basis of control group,the TC, TG,LDL,HDL,hs-CRP,IMT,plaque area and adverse reaction between two group were compared.Result：After 12 months’treatment,TC,TG,LDL,HDL,hs-CRP of the experimental group were statistically better than that of the control group（P〈0.05）.The plaque area and IMT of the experimental group were statistically lower than that of the control group（P〈0.05）.The adverse reaction between two group had no significant difference（χ2=1.375,P〈0.05）. Conclusion：Atovastatin calcium could improve the blood lipid level,reduce the inflammation response,has a stable and promote the ablation effect on plaque.