喹硫平治疗男性精神分裂症临床效应与剂量、血药浓度的关系

Relationship between serum concentration and clinical efficacy of quetiapine in treatment of male patients with schizophrenia

目的：探讨喹硫平治疗男性精神分裂症患者的血药浓度与临床疗效的关系。方法纳入63例住院男性精神分裂症患者；口服喹硫平片治疗8周，根据疗效和耐受性调整剂量。治疗4、8周末分析患者的血药浓度、疗效及副作用。结果4周喹硫平血药浓度与年龄（r＝0．297）、病程（P＝0．315）呈正相关，与文化程度（r＝－0．297）呈负相关；8周血药浓度与年龄呈正相关（r＝0．318）。4周喹硫平血药浓度与4周剂量存在正相关（r＝0．429）；8周喹硫平血药浓度与8周剂量存在正相关（r＝0．292）。喹硫平血药浓度与阳性和阴性症状量表PANSS减分率无明显相关（P＞0．05）。喹硫平治疗4、8周时的副作用与4周血药浓度存在正相关。结论喹硫平可有效治疗男性精神分裂症患者；年龄、剂量和副作用与血药浓度存在相关性。喹硫平血药浓度与临床疗效无明显关联。

Objective To examine the relationship between quetiapine serum concentration,dose,therapeu-tic efficacy and side effects in male patients with schizophrenia.Methods Sixty-three male patients with schizo-phrenia were collected.They were treated openly for 8 weeks with quetiapine,the dose was adjusted according to clini-cal improvement and tolerance.The plasma quetiapine concentrations,therapeutic efficacy and adverse drug reactions were observed after the 4 -week treatment period,and at the end of the 8 weeks of the treatment.Results After 4 weeks,the serum concentration had significant correlation with age,the disease duration and education level.After 8 weeks,there was significant correlation between serum concentration and age.We found a correlation between dose and serum concentration of quetiapine,and no relationship between serum concentration and PANSS scores.Side effects were correlated with 4 weeks′serum concentrations.Conclusion Quetiapine is effective for male patients with schizophrenia.Age,quetiapine dose and side effects have significant correlations with the serum concentration.It appears that plasma quetiapine concentration has no effects on therapeutic efficacy.