厦门市儿童病毒脑炎病例中肠道病毒感染情况分析

Analysis of enterovirus infection in children with virus encephalitis in Xiamen city

目的：通过对249例儿童病毒性脑炎的流行病学和病原学调查分析,探讨厦门市儿童病毒性脑炎中肠道病毒感染情况及特征,为厦门市病毒性脑炎的诊断与防治提供科学依据。方法对2011年5-9月在厦门市所有二级以上医疗机构临床诊断为病毒性脑炎的249例病例进行流行病学调查和实验室检测,采用描述性流行病学的方法进行统计分析。结果249例患者主要来自本地（76.7%）,12岁以下占72.77%,男性占67.87%,女性占32.13%,5-7月为发病高峰。临床主要表现为发热（92.37%）、头痛（87.15%）、呕吐（84.34%）等,共检出总肠道病毒阳性94例,其中3份CoxA16阳性,占3.19%,2份EV71阳性,占2.13%,其他肠道病毒阳性89份,占94.68%。对7份其他肠道病毒阳性的标本测序发现,ECHO 30阳性6份,占85.71%。结论2011年厦门市儿童病毒性脑炎中肠道病毒感染占37.8%,加强监测工作是预防和控制病毒性脑炎流行的关键。

Objective To provide scientific basis for diagnosis and prevention in Xiamen city of viral encephalitis,En-terovirus infection and epidemiology feature were studied by the investigation and analysis of epidemiology and pathogen in 249 cases of viral encephalitis. Methods Epidemiological investigation and laboratory test data of 249 cases with viral encephalitis from all hospital more than grade two between May to September in 2011 were collected,and then descriptive statistics is used to analyze the data. Results 249 patients were mainly from the local district（76. 7%） of Xiamen city and the age less than 12 years accounted for 72. 77%, which male accounted for 67. 87% and female accounted for 32. 13%. Tthe peak of incidence was from may to July. The main clinical manifestations were fever （92. 37%）, headache （87. 15%）, and vomiting （84. 34）. 94 of all patients were detected intestinal virus, which including 3 cases of CoxA16（ 3. 19%）, 2 cases of EV71（ 2. 13%） and 89 ca-ses of other enterovirus （ 94. 68%）. 6（85. 71%）samples of ECHO 30 were detected through sequencing method in 7 samples with other enterovirus positive. Conclusion 37. 8% of viral encephalitis from Xiamen city were infected by enterovirus in 2011, strengthen the monitoring work is the key to the prevention and control of viral encephalitis.