微生态制剂联合蓝光照射治疗新生儿黄疸疗效观察

Observation of curative effect by microecologics combined with blue light irradiation in the treatment of neonatal jaundice

目的观察微生态制剂联合蓝光照射治疗新生儿黄疸的疗效。方法 100例黄疸新生儿,随机分为三组。实验组34例,给予微生态制剂枯草杆菌二联活菌颗粒(妈咪爱)联合蓝光照射治疗;对照组33例,给予蓝光照射治疗;空白组33例,给予妈咪爱治疗。观察三组的治疗效果。结果治疗有效率以实验组最高(94.12%);黄疸减退时间以实验组最快[平均(37.72±3.78)h];治疗后72 h经皮胆红素较治疗前下降,以实验组最低[平均(139.78±38.33)μmol/L];与其他两组比较,差异均具有统计学意义(P<0.05)。不良反应发生率均较低,但实验组最低,三组比较,差异无统计学意义(P>0.05)。结论微生态制剂联合蓝光照射治疗新生儿黄疸临床效果确切,黄疸减退快速,不良反应少,适合在临床推广。

Objective To pbserve the curative effect of microecologics combined with blue light irradiation in the treatment of neonatal jaundice. Methods A total of 100 newborns with jaundice were randomly divided into three groups. Experimental group with 34 cases received microecologics bacillus subtilis duplex viable bacterium granule （Medilac-Vita） combined with blue light irradiation. Control group with 33 cases received blue light irradiation for treatment. Blank group with 33 cases received Medilac-Vita for treatment. Curative effects of the three groups were observed. Results The experimental group had the highest effective rate （94.12%） and the fastest disappearance time of jaundice [average time as （37.72±3.78） hi. In 72 h after treatment, the experimental group had the lowest level of transcutaneous bilirubin [average level as （139.78± 38.33） μmol/L]. The differences from the other two groups all had statistical significance （P〈0.05）. All three groups ha/t decreased incidence of adverse reactions, while the experimental group had the lowest one. Their difference had no statistical significance （P〉0.05）. Conclusion Combination of microecologics and blue light irradiation can provide precise effect in treating neonatal jaundice, with quick disappearance of jaundice and few adverse reactions. This method is suitable for clinical promotion.