无创气道正压通气联合生脉注射液治疗心力衰竭的临床研究

Clinical research of non-invasive positive airway pressure ventilation combined with Shengmai injection in the treatment of chronic heart failure

目的探讨无创气道正压通气联合生脉注射液对慢性心力衰竭(CHF)患者心功能以及心率的影响。方法 80例慢性心力衰竭患者随机分为治疗组和对照组,各40例。对照组采用常规治疗,治疗组在对照组治疗基础上,给予无创气道正压通气联合生脉注射液治疗,记录治疗前后患者的症状、心脏功能指标[左室射血分数(LVEF)、心输出量(CO)、心搏出量(SV)]、血气指标[血氧饱和度(Sa O2)、氧分压(PO2)、二氧化碳分压(PCO2)]情况。结果两组患者治疗后临床症状和Sa O2、PO2、PCO2均有所改善,CO、SV、LVEF均明显增高,且治疗组的效果明显优于对照组(P<0.05)。结论与传统治疗相比,无创气道正压通气联合生脉注射液治疗且能明显改善慢性心力衰竭患者心功能及心率。

Objective To investigate influence of non-invasive positive airway pressure ventilation combined with Shengmai injection on cardiac function and heart rate in chronic heart failure （CHF） patients. Methods A total of 80 chronic heart failure patients were randomly divided into treatment group and control group, with 40 cases in each group. The control group received conventional treatment, and the treatment group received additional non-invasive positive airway pressure ventilation combined with Shengmai injection. Records were made on symptoms, cardiac function indexes [left ventricular ejection fraction （LVEF）, cardiac output （CO）, stroke volume （SV）], and blood gas indexes [oxyhemoglobin saturation （SaO2）, partial pressure of oxygen （PO2）, partial pressure of carbon dioxide （PCO2）] before and after treatment. Results Both groups had improved clinical symptoms, SaO2, PO2, and PCO2, and their CO, SV, and LVEF were all obviously increased. The treatment group had much better effects than the control group （P〈0.05）. Conclusion Compared with traditional treatment, non-invasive positive airway pressure ventilation combined with Shengmai injection for treatment can effectively improve cardiac function and heart rate in chronic heart failure patients.