B型脑钠肽在慢性阻塞性肺疾病中的水平改变意义分析

Significance analysis of B-type brain natriuretic peptide level change in chronic obstructive pulmonary disease

目的探讨B型脑钠肽水平改变在慢性阻塞性肺疾病患者中的临床意义。方法 76例慢性阻塞性肺疾病患者,根据肺动脉压力是否升高分为A组(41例,肺动脉压升高)和B组(35例,肺动脉压正常),同时选择体检的健康者作为对照组(35例)。观察比较所选对象的血浆B型脑钠肽水平及所选对象的超声心动图检测结果。结果 A组肺动脉压力、B型脑钠肽水平高于B组和对照组,差异有统计学意义(P<0.05);A组右心室内径大于B组和对照组,差异均有统计学意义(P<0.05);A组左室射血分数低于B组和对照组,差异均有统计学意义(P<0.05)。结论慢性阻塞性肺疾病患者B型脑钠肽水平升高,与肺动脉压升高和右心功能不全关系密切,监测B型脑钠肽水平改变有重要的临床意义。

Objective To investigate the clinical significance of B-type brain natriuretic peptide level change in chronic obstructive pulmonary disease patients. Methods A total of 76 chronic obstructive pulmonary disease patients were divided by their pulmonary arterial pressure into group A （41 cases, increased pulmonary arterial pressure） and group B （35 cases, normal pulmonary arterial pressure）. Healthy people were selected as control group （35 cases）. Their plasma B-type brain natriuretic peptide level and ultrasonic cardiogram detection outcomes were observed and compared. Results The group A had higher levels of pulmonary arterial pressure and B-type brain natriuretic peptide than group B and the control group, and their differences all had statistical significance （P〈0.05）;its right ventricular internal dimension was larger than group B and the control group, and their differences all had statistical significance （P〈0.05）;its left ventricular ejection fraction was lower than group B and the control group, and their differences all had statistical significance （P〈0.05）. Conclusion Increased B-type brain natriuretic peptide level in chronic obstructive pulmonary disease patients is closely correlated with increased pulmonary arterial pressure and cardiac insufficiency. Thus monitoring on B-type brain natriuretic peptide level change contains important clinical significance.