甘精胰岛素治疗老年2型糖尿病患者的临床效果观察

Observation of clinical effect by insulin glargine in the treatment of senile type 2 diabetes mellitus patients

目的观察老年2型糖尿病患者采用甘精胰岛素治疗的临床效果。方法 120例患有2型糖尿病的老年患者,将其随机分为对照组和观察组,每组60例,对照组采用精蛋白锌重组赖脯胰岛素治疗,观察组采用甘精胰岛素治疗。对比两组疗效。结果观察组患者治疗后的低血糖的发生率(13.33%)明显低于对照组(41.67%),观察组患者治疗后餐后2 h的血糖和空腹血糖、血糖达标时间、糖化血红蛋白(Hb A1c)水平均好于对照组患者,两组比较差异具有统计学意义(P<0.05)。结论甘精胰岛素治疗老年患者2型糖尿病可缩短患者的血糖达标时间,治疗方案经济、安全、有效,临床价值较高。

Objective To observe the clinical effect of insulin glargine in the treatment of senile type 2 diabetes mellitus patients. Methods A total of 120 senile patients with type 2 diabetes mellitus were randomly divided into control group and observation group, with 60 cases in each group. The control group received insulin protamine zinc restructuring lispro for treatment, and the observation group received insulin glargine for treatment. Curative effects of the two groups were compared. Results The observation group had much lower incidence of hypoglycemia （13.33%） than the control group （41.67%） after treatment. The observation group also had better levels of 2 h postprandial blood glucose, fasting blood-glucose, blood glucose standard time, and glycosylated hemoglobin （HbA1c） than the control group. The differences between the two groups had statistical significance （P〈0.05）. Conclusion Insulin glargine can shorten blood glucose standard time in treating senile type 2 diabetes mellitus patients, and this method contains high clinical value as economical, safe and effective.