MTHFR及MTRR基因多态性与不良孕产的相关性研究

CORRELATION BETWEEN MTHFR AND MTRR GENE POLYMORPHISMS AND ADVERSE MOTHERHOOD

目的探究与分析5,10-亚甲基四氢叶酸还原酶(MTHFR)及甲硫氨酸合成酶还原酶(MTRR)与不良孕产的相关性。方法选取该院2013年6月—2014年6月收治的有生育要求的育龄妇女120例,将其按照有无不良孕产史分为二组,每组各60例,分别为不良孕产组与正常组,对二组育龄妇女的MTHFR及MTRR基因多态性进行检测与分析。结果不良孕产组中未发生风险患者12例(20.00%),正常组未发生风险患者20例(33.33%),正常组较不良孕产组相比未发生风险患者明显增多(χ2=4.78,P<0.05);不良孕产组中高度风险患者23例(38.33%),正常组高度风险患者11例(18.33%),不良孕产组较正常组组相比高度风险患者明显增多(χ2=5.12,P<0.05)。二组低度风险相比差异无统计学意义(χ2=2.55,P>0.05);不良孕产组中度风险患者分别为15例(25.00%),正常组中度风险患者16例(26.67%),二组中度风险相比差异无统计学意义(χ2=2.72,P>0.05)。结论 MTHFR及MTRR基因多态性与不良孕产具有一定的相关性,临床工作者可针对诊断结果给予早期治疗,以降低不良孕产的发生率。

Objective To explore and analyze the relationship between 5,10 - methylenetetrahydrofolate reductase （MTHFR）and methionine synthase reductase （MTRR）and bad motherhood.Methods A total of 120 cases of women of childbearing age in author＇s hospital from June 2012 to June 2014 were treated fer-tility requirements,according to the presence or absence of adverse pregnancy history were divided into two groups,60 cases in each group.Gene polymorphisms of MTRR of MTHFR were detected and analyzed. Results The no risk patients was 12 （20.00%）in adverse pregnancy group,20 cases （33.33%）in normal group,the former＇s risk was significantly increased （χ2= 4.78,P〈0.05）than the normal group.High-risk patients in adverse pregnancy group were 23 cases （38.33%）,11 （18.33%）in normal group,the difference was statistical significantly （χ2= 5.12,P〈0.05）.But low-risk and moderate-risk patients were no significant difference （χ2= 2.55,P〉0.05;χ2= 2.72,P〉0.05）between the two groups.Con-clusions There are certain relevance between MTHFR and MTRR gene polymorphisms and adverse preg-nancy.Clinicians should carry out diagnosis and early treatment to reduce the incidence of adverse pregnan-cy.