摘要
目的探讨大肠癌患者外周血中CD4+和CD8+T淋巴细胞亚群的变化以及与患者预后的关系。方法选取2012年6月—2014年6月到该院诊治的47例大肠癌患者作为研究对象,同时选取同期到该院接受体检的健康者作为对照研究。二组均抽取静脉血,采用流式细胞术检测外周血中CD4+和CD8+T淋巴细胞的比例以及CD4/CD8比例,并分析了CD4/CD8比例与患者早期大肠癌患者临床参数以及预后的关系。结果与对照组比较,观察组患者外周血中CD4+T淋巴细胞和CD4/CD8比例均显著下调(P<0.05),而CD8+T淋巴细胞比例则显著提高(P<0.05)。CD4/CD8比例与患者年龄、性别、组织分化程度和Dukes分期无关,而与淋巴结转移以及生存时间有关。结论 CD4+和CD8+T淋巴细胞水平反映了早期大肠癌患者的免疫功能,与淋巴结转移以及预后密切相关。
Objective To investigate the changes of peripheral blood CD4 and CD8 T lymphocyte subsets and the relationship between T lymphocyte subsets and prognosis.Methods Totally 47 cases of patients with colon cancer from June 2012 to June 2014 in author＆#39;s hospital were choose as observation group and 47 cases of healthy people were choose as control group.Peripheral blood from two groups was obtained,and CD4＋ ,CD8＋ T lymphocyte and CD4＋/CD8＋ ratio were analyzed by flow cytometry.The relationship of CD4＋/CD8＋ ratio and clinical parameters and prognosis were analyzed.Results Compared with con-trol group,CD4＋ T lymphocyte and CD4＋/CD8＋ ratio in observation group were significantly reduced （P 〈0.05）,while CD8＋ T lymphocyte significantly enhanced （P 〈0.05）.There was no relationship be-tween CD4＋/CD8＋ ratio and patients＆#39;age,gender,histological differentiation and Dukes staging.Therer was relationship between CD4＋/CD8＋ ratio and lymph node metastasis and survival time.Conclusion CD4＋ and CD8＋T lymphocyte levels reflect the early immune function of patients with colorectal cancer and is closely related to lymph node metastasis and prognosis.
出处
《中国煤炭工业医学杂志》
2015年第4期557-559,共3页
Chinese Journal of Coal Industry Medicine
