Matriptase与子宫内膜癌侵袭转移相关性的研究进展

Progress of the Correlation about Matriptase and the Invasion and Metastasis of Endometrial Cancer

侵袭和转移是恶性肿瘤的重要生物学特征之一,也是造成肿瘤患者死亡的主要原因。肿瘤的侵袭和转移是一个复杂的病理过程,涉及多种蛋白酶,包括基质金属蛋白酶和丝氨酸蛋白酶等。近来研究发现一种Ⅱ型跨膜丝氨酸蛋白酶Matriptase可通过激活尿激酶型纤溶酶原激活物、肝细胞生长因子/扩散因子、蛋白酶活化受体2和前列腺蛋白酶原促进肿瘤细胞的侵袭和转移,与多种恶性肿瘤,如乳腺癌、食管癌、前列腺癌、宫颈癌、卵巢癌、子宫内膜癌等的发生、发展密切相关。因而Matriptase有望成为恶性肿瘤一个新的诊断和治疗靶标。综述Matriptase与子宫内膜癌侵袭转移的相关性。

Invasion and metastasis is one of the important biological features of malignant tumor, which leads to the cancer patients deaths. Tumor invasion and metastasis is a complex pathological process involving many kinds of protease which including metal matrix protease, serine protease and so on. Recently, we found a type Ⅱ transmembrane serine protease named Matriptase which can enhance the process of tumor invasion and metastasis through activating urokinase-type plasminogen activator, hepatocyte growth factor/scatter factor, protease activated receptor 2 and prostate. It was closely related to the occurrence and development of a variety of malignant tumors, such as breast cancer, esophageal cancer, prostate cancer, cervical cancer, ovarian cancer and endometrial cancer, Thus, Matriptase is expected to become a new biomarker for tumor diagnosis and a promising treatment target. Now we will discuss the eolTelation about Matfiptase and the invasion and metastasis of endometrial cancer.