脂质代谢紊乱与子宫内膜癌的相关性研究

Research of the Correlation between Lipid Metabolic and Endometrial Cancer

血浆中脂类统称为血脂,包括三酰甘油(TG)、磷脂、胆固醇及其酯、游离脂肪酸等。脂质代谢紊乱一般是TG升高与高密度脂蛋白胆固醇(HDL-C)降低。自从1994年发现瘦素以来,脂质代谢传统作用(比如提供能量、合成激素等)以外的作用逐步被发现。如脂质代谢与心血管疾病、恶性肿瘤具有相关性;血浆中三酰甘油的升高与子宫内膜癌的发病具有相关性,但尚未发现高密度脂蛋白降低是子宫内膜癌发病的危险因素之一;胰岛素抵抗在子宫内膜癌的发生发展中具有重要作用,脂质代谢可能通过胰岛素抵抗途径对子宫内膜癌的发生和发展有一定的影响;脂质代谢过程相关物质,如瘦素、脂联素、固醇调节元件结合蛋白(SREBPs)、过氧化物酶体增殖物激活受体(PPAR)可能与子宫内膜癌具有相关性。

In plasma lipids are collectively referred to as lipid, including triglycerides, phospholipid, cholesterol and the ester, free fatty acids, etc. Lipid metabolism disorder is generally elevated tfiglycerides （TG） and low high-density lipoprotein cholesterol （HDL-C）. Since leptin found in 1994, people begin to discover the roles except the traditional ones of lipid metabolism （such as energy, synthetic hormones, etc.）. Many studies suggest the correlations between lipid metabolism and cardiovascular diseases, malignant tumors. Researchers found that elevated triglycerides in the blood plasma associated with the pathogenesis of endometrial carcinoma, however, the study has not yet found that low HDL-C is one of the pathogenesis of endometrial cancer risk factors. The current studies have found the correlations between lipid metabolic disorder and endometrial cancer. Lipid metabolic may effect on endometrial cancer by insulin resistance that plays an significant role in endometrial cancer development. Studies have found that lipid metabolism related substances, such as leptin, sterol regulating element binding proteins （SREBPs）, peroxidase body growth activated receptor（PPAR）, may be related to endometrial cancer.