年龄、绝经状态与同型半胱氨酸水平的关系

The Relationship between Age, Menopausal Status and Homocysteine Level

目的：探讨年龄、绝经状态与同型半胱氨酸（Hcy）水平的关系。方法：搜集2012年1月—2013年10月首都医科大学附属北京友谊医院妇科门诊就诊患者450例（绝经过渡期女性123例,绝经后女性327例）,年龄45-65岁、未应用过激素替代疗法（HRT）治疗,抽取空腹肘正中静脉血测量血清同型半胱氨酸水平。结果：450例患者Hcy水平为5.7-45.4μmol/L,平均（8.4±3.1）μmol/L。不考虑绝经状态和绝经时间,体质量指数（BMI）未分层和分层后,不同年龄的女性血清Hcy水平差异有统计学意义（均P〈0.05）。不考虑年龄因素,不同绝经状态和绝经时间的女性,血清Hcy水平差异无统计学意义（均P〉0.05）。校正年龄和BMI后不同绝经状态和绝经时间的女性Hcy水平差异无统计学意义（F=30.67,P〉0.05）。结论：不考虑绝经状态和绝经时间,不同年龄组血清Hcy水平存在差异,将BMI进行分层后,年龄仍然影响同型Hcy水平。但校正年龄和BMI后,血清Hcy水平与绝经状态无关。在绝经后妇女中,Hcy水平并不随着绝经时间的改变而改变。

Objective： To investigate the relationship between age, menopausal status and homocysteine levels. Methods： We collected 450 patients from Beijing Friendship Hospital gynecological clinic （123 patients were in menopausal transition period and 327 patients were postmenopausal period）. Patients aged 45-65 years old never used HRT were measured homocysteine levels in fasting venous blood. Results：Of the 450 patients, the homocysteine level was an average of （8.4±3.1） μmol/L, 5.7-45.4 μmol/L. Without considering the menopausal status and menopausal years, before and after stratification by the body mass index, homocysteine level in different age groups showed significantdifferences （P〈0.05）. Without considering age, the homocysteine levels were not significant differences between different menopausal status and menopausal years （P〉0.05）. After adjusting the age and BMI, the homocysteine levels were not significantly different between different menopausal status and menopausal years （F=30.67,P 〉0.05）. Conclusions：Without considering the, menopausal status and menopausal years, age is the main factor affecting homocysteine level of women, stratificated by the body mass index, age still affects homocysteine level significantly. After adjusting the age and BMI, the homocysteine levels were not significant different between different menopausal status, homocysteine level did not change with the menopausal years.