血管生成素与妊娠

Angiopoietins and Pregnancy

血管生成素(Angs)是近年来研究发现的一组促血管生成的调节因子,由血管内皮细胞分泌,其在血管的发生、发展过程中发挥着重要的作用。Ang-1和Ang-2促进肿瘤血管的生成和肿瘤细胞的浸润,妊娠过程中,胚胎的植入和肿瘤的浸润过程是相似的,Angs及其受体酪氨酸激酶-2受体(Tie-2)在胎盘和胎儿中都有表达,对胚胎的植入、胎盘血管的生成以及胎儿的生长发育都有重要的作用。因此,在妊娠过程中,如果任何一个环节出现血管生成障碍,将会导致胚胎植入失败或妊娠并发症等的发生。对Angs对妊娠作用的进一步研究,将有助于妊娠期疾病的诊断、治疗。

The angiopoietins （Angs） are a novel family of newly-discovered angiogenic factors which are secreted by vascular endothelial cells, plays an important role in regulating angiogenesis, degeneration and vessel stabilization. Ang-1 and Ang-2 participate in the development of embryonic blood vessels, as well as the angiogenesis and metastasis of tumors. Embryo implantation is similar with tumor during pregnancy, therefore, Angs and the tyrosine kinase Tie-2 receptor reside in both placenta and fetus, the expression of Angs during pregnancy may represent a feature for embryo implantation, placental angiogenesis, as well as the growth of the fetus. Hence, in the process of pregnancy, if anyone link in angiogenesis barrier, will cause the failure of embryo and the occurrence of pregnancy complications. Therefore, Angs for further study of the role of pregnancy, will help to gestational disease diagnosis and treatment.