摘要
采用柠檬酸钠还原氯金酸的方法,制备出粒径均一的金纳米粒子(AuNPs),通过加入二水合双(对-磺酰苯基)苯基膦化二钾盐(BSPP),增强了AuNPs体系的分散性与稳定性.选用直径为15和40nm的AuNPs,用不同序列巯基修饰的单链DNA连接到其表面,通过DNA链的杂交,形成不同结构的金纳米粒子组装体.通过改变加入DNA延长连接单元的比例,可以控制金纳米粒子组装体具有连续离散型的1∶1,2∶1和3∶1纳米结构.
Gold nanoparticles (AuNPs) with different sizes (15 and 40 nm) were prepared by reducing chlorauric acid with sodium citrate. The stability of AuNPs was increased when bis(p-sulfonatophenyl)pheny- lphosphine (BSPP) was used as ligand because of its large molecule size and electro-negativity in water. The assemblies of AuNPs were obtained when AuNPs with different particle sizes were conjugated with two thiol- terminated, single-stranded, and complementary DNA ( HS-DNA), respectively, and hybridized each other. The results indicated that AuNPs assemblies could have controllable, continuous and discrete nanostructures with molar ratios of 1 : 1,2 : 1 and 3 : 1 in the presence of BSPP and with extended strands of DNA as linkers.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2015年第5期844-849,共6页
Chemical Journal of Chinese Universities
基金
国家自然科学基金(批准号:21172171)
天津市自然科学基金(批准号:12JCQNJC08600
15JCYBJC20500)资助~~