低浓度罗哌卡因在婴儿唇裂术后的镇痛研究

The Postoperative Analgesia Study of Low-concentration Ropivacaine in Infants with Cleft Lip Repair

目的:探讨低浓度罗哌卡因局部麻醉在婴儿唇裂修复术后的镇痛效果和安全性。方法:唇裂修复术婴儿80例随机分为对照组(0.5%利多卡因)和3个实验组(R1组0.15%,R2组0.2%和R3组0.25%罗哌卡因)。患儿全麻后予局麻药术区局麻,记录患儿术后1、2 h疼痛评分。结果:各组均安全度过围术期,对照组术后疼痛评分均明显高于R2、3组(P<0.05);R2、3组术后1、2 h疼痛评分均<3分,两组评分差异比无统计学意义。结论:0.2%罗哌卡因局部麻醉在婴儿唇裂修复术后镇痛效果好,安全性可。

Objective： To study the postoperative analgesic effect and safety of low-concentration ropivacaine which used to local infiltration anesthesia in infants with cleft lip repair. Method： Eighty infants with cleft lip repair were randomly divided into control group （0.5% lidocaine） and R1-3 experimental groups （0.15%, 0.2% and 0.25% ropivacaine）. The pain scores were recorded 1-2 hours after operation in infants. Results： All the groups didn＇t happen any serious adverse reactions in the perioperative period. The pain score in the control group were apparently higher than that of R2, 3 groups （P〈0.05）. The pain scores were both less than 3 points 1-2 hours after operation in the R2, 3 groups. Conclusion： The ropivaeaine （0.2%） has the better analgesia effect and safety in infants with cleft lip repair.