再论羟乙基淀粉风波及其临床应用

Rediscussion on the incident of hydroxyethyl starch and its clinical application

背景羟乙基淀粉（hydroxyethyl starch，HES）临床应用的利弊一直是学术界争论的焦点。2010年证实Boldt教授所作的多篇研究HES的论文为学术造假，更引发了一场关于HES的“全球研讨会”。目的概述近年来HES临床研究的相关文献及其临床应用的观点。内容Boldt教授的风波；HES对脓毒症患者与非脓毒症患者的预后影响不同；HES对肾功能的影响可能与剂量相关。趋向HES有其临床使用的价值，合理地选择使用，可扬其所长避其所短。

Background The advantages and disadvantages about the clinical application of hydroxyethyl starch （HES） are always an academic debate. The global discussion on HES has been initiated and further deepened by serials of academic counterfeits from professor Boldt since 2010. Objective To review the relevant literatures of hydroxyethyl starch and the opinions on its clinical application. Content The incident of professor Boldt＇s academic counterfeits, the different outcomes of HES in patients with or without sepsis, and a dose-dependent effect of hydroxyethyl starch on the renal function. Trend Under certain conditions, HES shows its clinic value. However, special attention should be paid in terms of its advantages and disadvantages.