酪氨酸激酶-信号转导和转录激活因子信号通路参与神经病理性疼痛的研究进展

The progress of janus kinases-signal transducer and activators of transcription signaling pathway in neuropathic pain

背景神经病理性疼痛（neuropathic pain，NP）是一种最常见的、最棘手的慢性疼痛之一。酪氨酸激酶信号转导和转录激活因子（janus kinases-signal transducer and activators of transcription, JAKs-STATs）信号通路是介导细胞反应的重要信号通路系统，近年有研究表明JAKs-STATs信号通路参与NP。目的探讨JAKs-STATs信号通路参与NP的机制。内容分别从JAKs-sTATs信号通路生物学特性、JAKs-STATs信号通路对NP调节机制的研究现状进行综述。趋向为更好地治疗NP提供理论依据。

Background Neuropathic pain （NP） is one of the most common and tricky chronic pain. Janus kinases signal transducer and activators of transcription （JAKs-STATs） signaling pathway is an important signaling pathway in mediating cell reaction system. In recent years, studies have shown that JAKs-STATs signaling pathway is closely related to NP. Objective To explore the mechanisms of JAKs-STATs signaling pathway in NP. Content This article firstly reviewed the biological characteristics of JAKs-STATs signaling pathway; then reviewed the current studies about the regulating mechanism of JAKs-STATs signaling pathway in NP. Trend It provides a new theory basis for the treatment of NP.