药物性皮炎与病毒感染的情况调查

The survey of drug dermatitis and virus infection

目的 通过分析在我院接受治疗的132例药物性皮炎患者的临床资料,对患者的HHV6、HHV-7疱疹病毒以及PVB19细小病毒的感染程度进行调查分析.方法 运用酶联免疫吸附法对在我院接受治疗的药物性皮炎患者以及正常对照患者的血清进行病毒抗体的检测;综合分析患者的性别、年龄、患病类型、致病药物等与病毒感染的相关性.结果 HHV-6在药物超敏反应综合征组（DIHS）、重症药疹组、一般药疹组、对照组的阳性感染率分别是31.0％、11.7％、7.3％、0％;HHV-7在药物超敏反应综合征组（DIHS）、重症药疹组、一般药疹组、对照组的阳性感染率分别是31.0％、19.35％、9.8％、10.0％;PVB19在药物超敏反应综合征组（DIHS）、重症药疹组、一般药疹组、对照组的阳性感染率分别是0％、6.4％、4.9％、6.7％.结论 HHV-6、HHV-7的感染与药物超敏反应综合征组（DIHS）、重症药疹组发病存在相关性,PVB19感染与两组发病无关,因此,药物性皮炎病情严重与病毒感染有很大联系.

Objective To observe the viral infections of HHV-6,HHV-7 and PVB19 based on the clinical data of 132 patients with drug eruption treated in our hospital.Methods Viral antibody was detected using enzyme-linked immunosorbent method and the correlation was analyzed based on the patient＆#39;s gender,age,disease types,pathogenic drugs and viral infection.Results The positive rates of the HHV-6 in drug hypersensitivity syndrome group （DIHS group）,severe drug eruption,eruption group and control group were 31.0%,11.7%,7.3% and 0%,respectively.The positive rates of HHV-7 in drug DIHS group,severe drug eruption,eruption group,control group were 31%,19.35%,9.8% and 10%,respectively.The positive rates of PVB19 in DIHS group,severe drug eruption,eruption group,control group were 0%,6.4%,4.9% and 6.7%,respectively.Conclusions HHV-6,HHV-7 infection was closely related to the DIHSand severe drug eruption.