慢性乙肝患者血清HBV DNA载量与HBV-M、ALT、AST含量的关系研究

Relationship between HBV DNA load and HBV-M, ALT, AST content in the serum of chronic hepatitis B patients

目的 分析慢性乙型肝炎患者血清HBV DNA与乙肝标志物（HBV-M）、肝功能ALT、AST的关系,以期对慢性乙肝患者的防治提供借鉴.方法 选取在2011年4月至2012年6月入住我院慢性乙肝患者100例为研究对象,搜集乙肝六项、肝功能等资料,探讨HBV DNA载量与HBV-M、ALT、AST含量的关系.结果 各阳性模式的病毒载量比较,大三阳病毒载量高于其他组,差异有统计学意义（P＜0.05）,其他各组比较,差异无统计学意义（P＞0.05）.阳性率比较,大三阳高于其他组,差异有统计学意义（P＜0.05）,其他各组比较,差异无统计学意义（P＞0.05）.血清HBV DNA载量与血清HBeAg滴度无相关性（r=0.683,P＞0.05）;血清HBV DNA载量与HBsAg含量无相关性（r=-0.483,P＞0.05）;血清HBV DNA载量与ALT无相关性（r=-0.157,P＞0.05）,血清HBV DNA载量与AST水平也无相关性（r=0.062,P＞0.05）.结论 大三阳血清HBV DNA载量、病毒阳性率均高于其他阳性模式;但血清HBV DNA定量值的高低与HBV-M、ALT、AST含量无相关性,所以,HBV DNA可反映HBV在外周血的复制情况,并不能反映肝脏损伤程度及预后.

Objective To analyze the relationship between HBV DNA load and HBV-M,ALT,AST content in the serum of patients with chronic hepatitis B,and to provide reference for the prevention and treatment of patients with chronic hepatitis B.Methods 100 patients with chronic hepatitis B were selected as research subjects from April 2011 to June 2012 in our hospital.Hepatitis B six,liver function and other information were collected and the relationship between HBV DNA load and HBV-M,ALT,AST content was analyzed.Results Viral load of HBeAg group was higher than that of the other positive mode （P 〈 0.05）,and there was no statistically significant among all other groups.Viral positive rate of HBeAg group was high-er than that of the other groups （P 〈 0.05）,and there was no statistically significant among all other groups （P 〉 0.05）.There had no correlation between serum HBV DNA load and serum HBeAg titer （r =0.683,〉 0.05）.There had no correlation between HBV DNA load and HBsAg serum （r =-0.483,P 〉 0.05）.There had no correlation between serum HBV DNA load and ALT （r =-0.157,P 〉 0.05）.There had no correlation between serum AST levels,HBV DNA load,and AST （r =0.062,P 〉 0.05）.Conclusions HBV DNA load and viral positive rate of HBeAg group than that of the other positive mode,but the level of serum HBV DNA quantitative values and HBV-M,ALT,AST showed no correlation.Therefore,HBV DNA load could reflected the HBV replication situation and could not explain the degree of liver injury and prognosis.