美托洛尔治疗老年慢性心力衰竭100例的临床研究

A clinical study on 100 cases of elderly patients with chronic heart failure treated with metopro lol

目的：探讨美托洛尔治疗老年慢性心力衰竭的临床应用和疗效。方法：选取我院在2012年1月-2014年1月收治的老年CHF患者100例，随机分为实验组和对照组，对照组给予常规治疗，实验组加用美托洛尔治疗，治疗6个月后比较2组疗效和安全性。结果：实验组共46例患者治疗总有效，明显大于对照组（35例，P＜0．05）；实验组治疗后的心率、收缩压指标明显小于对照组（P＜0．05），LVEF明显大于对照组（P＜0．05），LVEDD、LVESD明显小于对照组（P＜0．05）；但不良反应发生率明显大于对照组（P＜0．05）。结论：美托洛尔治疗老年慢性心力衰竭可明显提高疗效，改善心功能指标，干预心室重构，但会增加不良反应发生率，因此应在医生指导下给予个体化治疗，降低不良反应，提高耐受性。

Objective：To investigate the clinical application and curative effect of metoprolol in the treatment of elderly patients with chronic heart fallure.Methods：select 100 cases in our hospital in 2012 January to 2014 January were elderly patients with CHF, randomly divided into the experimental group and the control group, the control group was given conventional treatment, the experimental group with metoprolol treatment, compared two groups of treatment efficacy and safety of 6 months.Results：patients in test group 46 cases total effective treatment, significantly higher than the control group （35 case,s P〈0.05）;experimental group after treatment, the heart rate, systolic blood pressure index was obviously less than that of the control group （P〈0.05）, LVEF was obviously higher than that of control group （P〈0.05）, LVEDD, LVESD were significantly lower than that of control group （P〈0.05）;but the bad reaction rate was obvi-ously higher than that of control group （P〈0.05）.Conclusion：It could significantly improve the efficacy of metoprolol in treatment of elderly patients with chronic heart fallure, improve the index of heart function, ventricular remodeling intervention, but it will increase the incidence of adverse reaction, and therefore should be given individual treatment under the guidance of a doctor, to reduce adverse reac-tions, improve the tolerance.