甲氧基喜树碱纳米粒子的制备及其体外释放研究

Preparation and Characterization of Controlled-release Formulations for Methoxycamptothecin Nanoparticles

采用乳化溶剂挥发的方法制备MeOCPT纳米粒子，结果表明：MeOCPT纳米粒子具有明显的圆形结构，且表面光滑，大小均匀，粒度分布在100～300nm之间。MeOCPT的栽药量和包封率分别为（3．10±1．19）％和（83．57±3．45）％，在体外可以持续缓慢释放，累积释放率接近60％，达到了预期的药物缓慢释放及降低毒性的结果。

The nanoparticles contained MeOCPT prepared with the method emulsion and solvent evaporation.The MeOCPT nanoparticles had a circular structure,with a smooth surface ,uniform size, and its particle size distributed between 100 nm and 300 nm.The drug-loading rate and entrapment efficiency of MeOCPT nanoparticles were （3.10± 1.19 ）% and （83.57±3.45）%.MeOCPT nanoparticles released slowly and lastingly in vitro whose cumulative release rate was nearly 60%,which could release the drugs slowly and reduce the toxicity of drugs.