泛素结合结构域与泛素化信号的识别

Recognition of Ubiquitination Signal with Ubiquitin-binding Domains

泛素化（Ubiquitylation，UB）是目前最为复杂最为多元的翻译后修饰，几乎参与胞内所有的生物学过程。其通过改变底物的分子景观（landscape）、三维结构、位置、活性、影响底物蛋白与其他蛋白的相互作用等方法，从时间和空间上调节底物所参与的生物学过程。而泛素化底物功能的发挥依赖于特异性的泛素结合结构域（Ubiquitin binding domains， UBDs）。UBDs 的表面功能基团特异性识别具有不同修饰类型的泛素化底物，并决定其功能的特异性。已知的20多种UBDs 超家族对泛素化信号网络的有序调节是人们开启泛素化网络的一把钥匙，同时了解 UBD-ubiquitin 的特异性识别是认识泛素化蛋白质组学“ubiquitome”的基础。

Ubiquitylation is a highly versatile post-translation modification that controls virtually all types of cellular events by changing the molecular landscape,the three-dimensional structure,the location or activity of the substrate,influencing the interactions of substrate with other proteins.Many cellular activities of ubiquitin and its functions are deciphered by specific ubiquitin binding domains （UBDs）.UBD interacts with the different type of Ubiquitylation with a variety of lengths and linkage patterns based on the specific functional surfaces.So far over twenty distinct UBD families have been identified,and the known members of this group have expanded rapidly.The UBD families,the decoder of ubiquitylation network,are building a foundation for in-depth understanding the ubiquitination proteomics “ubiquitome”.