益智煎治疗脾肾两虚型轻度认知功能障碍35例

Mild Cognitive Impairment Patients with Deficiency of Spleen and Kidney Syndrome Treated by Yizhijian:35 cases Report

目的:观察益智煎对脾肾两虚型轻度认知障碍患者认知功能和听觉事件相关电位P300的影响。方法:将70例轻度认知障碍患者随机分成两组,治疗组35例,治以益智煎;对照组35例,治以益智煎模拟剂。应用简易精神状态检查量表(MMSE)评定两组患者认知功能状况,并进行听觉事件相关电位P300检查。结果:治疗组总有效率80%,对照组40%,两组疗效比较有高度统计学意义(P<0.01),治疗组MMSE评分显著提高,P300潜伏期缩短、波幅提高,与治疗前比较有高度统计学意义(P<0.01),与对照组治疗后比较有高度统计学意义(P<0.01),两组治疗期间无严重不良反应。结论:益智煎能有效治疗脾肾两虚型轻度认知障碍患者。

Objective：To observe the effects of Yizhijian on the cognitive function event related potential P300 of mild cognitive impairment patients with deficiency of spleen and kidney syndrome. Methods：Total 70 patients with mild cognitive impairment were randomly divided into two groups,treatment group treaded with Yizhijian was 35 cases,control group treated with Yizhijian simulation agent was 35 cases. Application scale mini-mental state examination（MMSE） and event related potential P300 to assess effect of the two groups. Results：The total effective rate in treatment group and in control group was 800/0 and 40% ,the difference was statistically significant（P〈0.01）. In treatment group,MMSE scores improved,P300 latency reduced ,amplitude increased,with marked difference as compared with those before the treatment. There were significant difference compared with control group（P〈0.01）. There were no serious adverse reactions in two groups during the treatment. Conclusion：Yizhijian can improve the cognitive function of mild cognitive impairment patients with deficiency of spleen and kidney syndrome.