摘要
目的:探讨10日序贯疗法对幽门螺杆菌阳性消化性溃疡患者的治疗效果。方法:选取本院收治的幽门螺杆菌阳性消化溃疡患者90例,将患者随机分为试验组和对照组,每组45例。对照组采用三联疗法,奥美拉唑肠溶胶囊20 mg/次,阿莫西林100 mg/次,克拉霉素50 mg/次,联合用药,2次/d,口服,治疗10 d为1个疗程。试验组采用10日序贯疗法,前5天,予奥美拉唑肠溶胶囊20 mg/次,阿莫西林100 mg/次,2次/d,口服;后5天,予奥美拉唑肠溶胶囊20 mg/次,克拉霉素50 mg/次,甲硝唑40 mg/次,联合用药,2次/d,口服,前后一共10 d为1个疗程。治疗后观察两组患者的幽门螺杆菌的根除情况、临床疗效以及复发例数。结果:(1)治疗后,试验组治疗幽门螺杆菌根除情况优于对照组,差异有统计学意义(P<0.05)。(2)治疗后,试验组患者治疗总有效率明显优于对照组,差异有统计学意义(P<0.05)。(3)治疗后,试验组的复发率明显低于对照组,差异有统计学意义(P<0.05)。结论:10日序贯疗法在幽门螺杆菌阳性消化性溃疡治疗中效果显著,能够促进溃疡愈合,从而改善患者临床症状,降低复发率。
Objective: To investigate the clinical efficacy of clinical patients with Helicobacter pylori positive peptic ulcer 10 day sequential therapy.Method: 90 patients with Helicobaeter pylori positive peptic ulcer in our hospital were selected, and randomly divided into experimental group and control group, 45 cases in each group. The control group used the triple therapy of Omeprazole enteric coated capsules 20 mg/times, Amoxicillin 100 mg/times, Clarithromyein 50 mg/times, combined use of drugs, 2 times a day, for 10 days as a course of 1. In the experimental group, 10 day sequential therapy, 5 days ago, to the enteric coated Omeprazole capsule 20 mg/times, Amoxicillin 100 mg/times, 2 times a day. After 5 days, to the enteric coated Omeprazole capsules 20 mg/times, Clarithromycin 50 mg/times, Metronidazole 40 mg/times, the drug combination, 2 times a day, and a total of 10 days to 1 course. After treatment of Helicobacter pylori in two groups of patients, the clinical curative effect of eradication and recurrence rate were observed. Result: ( 1 ) After the treatment, the experimental group therapy for Helicobacter pylori eradication situation better than the control group, the difference was statistically significant ( P〈0.05 ) . ( 2 ) After the treatment, the patients in the experimental group the total effective rate was significantly better than the control group, the difference was statistically significant (P〈O.05) . ( 3 ) After treatment, the experimental group the recurrence relapse rate was significantly lower than that of the control group, the difference was statistically significant (P〈0.05) . Conclusion: The effect of 10 day sequential therapy in Helicobacter pylori positive peptic ulcer treatment significantly, can promote ulcer healing, so as to improve clinical symptoms, reduce relapse rate.
出处
《中国医学创新》
CAS
2015年第12期44-47,共4页
Medical Innovation of China
基金
广东省医学科学技术研究基金(WSTJJ20121010441501197105190516)
关键词
序贯疗法
幽门螺杆菌
消化道溃疡
Sequential therapy
Helicobacter pylori
Peptic ulcer