解毒化浊汤联合西药治疗糖尿病酮症酸中毒随机平行对照研究

Detoxification Huazhuo soup combined Western Treatment Medicine Diabetic Ketoacidosis Parallel Randomized Controlled Study

[目的]观察解毒化浊汤联合西药治疗糖尿病酮症酸中毒疗效。[方法]使用随机平行对照方法,将52例住院患者按就诊顺序号法简单随机分为两组。密切监测各项生命指征和身体各项指标。对照组26例常规治疗,予静脉输液,纠正电解质紊乱和快速扩容,并改善缓和循环系统功能。治疗组26例速效胰岛素,定期检测血糖、尿糖、尿酮体等指标,待病情稳定,予普通胰岛素;解毒化浊汤(生石膏30g,黄连9g,石菖蒲12g,黄芩、天花粉各10g,葛根20g,紫苏叶、藿香各10g;恶心呕吐加代赭石30g,竹茹10g;腹泻加白术、苍术各10g;发热加牡丹皮10g,水牛角30g),1剂/d,水煎取200m L,早晚温服。连续治疗7d为1疗程。观测临床症状、血糖、不良反应。连续治疗2疗程,判定疗效。[结果]治疗组显效20例,有效5例,无效1例,总有效率96.15%。对照组显效16例,有效2例,无效8例,总有效率69.23%。治疗组疗效优于对照组(P<0.01)。[结论]解毒化浊汤联合西药治疗糖尿病酮症酸中毒疗效满意,无副作用,值得推广。

[Objective]To observe the detoxification Huazhuo Tang combined effect of western medicine diabetic ketoacidosis. [Methods]Randomized parallel-group method using the 52 cases of hospitalized patients treatment order number method is simple and randomly divided into two groups. Close monitoring of vital signs and physical indicators. The control group 26 cases of conventional treatment, intravenous fluids to correct electrolyte imbalance and rapid expansion, and improved ease circulatory system function. Treated 26 cases of rapid-acting insulin, regular testing of blood glucose, urine, urine ketone and other indicators, to be in stable condition, to regular insulin; detoxification Huazhuo soup （Shengshigao 30g, I-Iuanglian 9g, Shichangpu 12g, Huangqi,Tianhuafen lOg, Gegen 20g, Zisuye,Huoxiang each lOg; nausea and vomiting plus Daizheshi 30g, Zhuru 10g; diarrhea plus Baizhu,Cangzhu 10g; fever plus Mudanpi 10g, Shuiniujiao 30g）, 1 a / d, decoction taken 200mL, morning and evening temperature clothes. 7d continuous treatment for a course of treatment. Observation of clinical symptoms, blood sugar, adverse reactions. 2 courses of continuous treatment, to determine efficacy. [Results]Treatment group 20 cases, effective in 5 cases, one case, the total efficiency 96.15%. The control group 16 cases markedly effective in 2 cases, 8 cases, the total efficiency 69.23%. Treatment group than in the control group （P〈0.01）. [Conclusion]Detoxification combined with western medicine decoction Huazhuo diabetic ketoacidosis results were satisfactory, no side effects, it is worth promoting.