临床痊愈期双相障碍患者及其健康同胞的注意功能比较

Attention Funcion in Recovered Patients with Bipolar Disorder and Their Healthy Siblings

目的:探讨临床痊愈期双相障碍患者及其健康同胞的注意功能。方法:选用连续操作测验(continues performance test,CPT)和倒行掩蔽测验(backward mask test,BMT),对36例临床痊愈期双相障碍患者(患者组)及其36名健康同胞(同胞组),以及36名健康对照者(对照组)的注意功能进行评估。结果:患者组的CPT2、BMT1和BMT2的成绩均低于对照组。患者组的CPT2、BMT1、BMT2、BMT3和BMT成绩均低于同胞组。同胞组CPT1、BMT1、BMT2、BMT3和BMT成绩均低于对照组。结论:双相障碍存在注意力的持续性、分配和激活缺陷,易受无关刺激干扰,其健康同胞也存在持续注意缺陷。

Objective： To explore the attention function in the recovered patients with bipolar disorders and their healthy siblings. Methods： The attention was assessed in 36 recovered patients with bipolar disorders and 36 their healthy siblings, and 36 healthy controls, by using the continuous performance test（CPT） and the backward mask test（BMT） of the coglab software package. Results： The patients showed lower scores of CPT2, BMT1, and BMT2 than those of the controls,and lower scores of CPT2, BMT1, BMT2, BMT3 and BMT than those of the siblings. The siblings showed lower scores of CPT1, BMT1, BMT2, BMT3 and BMT than those of the controls. Conclusion： The in bipolar disorders suffer from attention deficits in its persistence, allocation and activation, which were vulnerable to be interfered by irrelevant stimuli. Deficit in attention persistence also exists in the healthy siblings of schizophrenia patients, suggesting its potential genetic desposition for this severe mental disorder.