低血铅暴露与神经系统症状的关系

Association between low blood lead exposure and nervous system symptoms

目的探讨油漆工人的低血铅暴露与神经系统症状之间的关系。方法采用整群抽样的方法，抽取2个油漆相关企业的所有接触油漆的工人为样本，对其进行问卷调查、生化检测及体格检查。采用单因素）c2检验和多因素非条件logistic回归分析的方法探讨低血铅和其他因素暴露对神经系统症状的影响。结果收集到完整资料的有525例，其中血铅阳性者55例（10．5％）；血铅阳性者的血铅均值为（0．0884±O．0539）mg／L；278例（52．95％）出现类神经征；69例（13．14％）出现周围神经病症状。多因素非条件logistic回归分析显示：工龄（OR=1．827）、饮酒（OR=1．607）、健康状况（OR=3．862）、血铅（OR=1．983）与类神经征有关。工龄（OR=2．282）、饮酒（OR=2．704）与周围神经病有关。结论低浓度血铅暴露可能与类神经征的发生相关。

Objective To explore the association between low blood lead exposure and nervous system symptoms among the workers exposed to oil paint. Methods Through cluster sampling, workers with occupational oil paint exposure in 2 factories were selected to conduct a questionnaire survey, biochemical detection and health examination. Х^2 test and unconditional logistic regression analysis were performed for the determinants analysis. Results A total of 525 oil paint workers completed the survey, in whom, 55 （ 10.5% ） were blood lead positive, the mean of blood lead concentration was （0.088 4 ___ 0.053 9）mg/L, 278 （52.95%） had nervous system like symptoms and 69 （13.14%） had peripheral neuropathy symptoms. Multinomial logistic regression analysis showed that working age （OR= 1.827）, drinking （OR= 1.607）, health status （OR=3.862）, blood lead （OR.= 1.983） were risk factors for nervous system like symptoms. Working age （OR=2.282）, and drinking （OR=2.704） were risk factors for peripheral neuropathy. Conclusion Low blood lead exposure might be associated with nervous system like symptoms.