特发性肺纤维化患者血清IL-13、TGF-β1、IL-8水平及与肺功能的相关性

Serum IL-13, TGF-β1, IL-8 levels in idiopathic pulmonary fibrosis and correlation with lung function

目的探讨特发性肺纤维化患者血清IL-13、TGF-β1、IL-8水平。方法选择在我院治疗的肺纤维化患者60例为研究对象,另选择健康志愿者60例为对照组,检测两组患者血清IL-13、TGF-β1、IL-8水平,并测定动脉血气分析及肺功能相关指标。结果肺纤维化组血清IL-13、TGF-β1、IL-8水平显著高于对照组(P<0.01)。TGF-β1、IL-8与FVC占预计值的百分比呈显著负相关(P<0.01);TGF-β1、IL-13与FEV1占预计值的百分比呈显著负相关(P<0.01);TGF-β1与Pa O2呈显著负相关,TGF-β1、IL-13与P(A-a)O2呈显著正相关(P<0.01);IL-8与Pa O2、Sa O2呈显著负相关(P<0.01)。结论特发性肺纤维化患者血清IL-13、TGF-β1、IL-8水平显著升高,并且与患者肺功能具有负相关关系。

Objective To discuss serum IL-13, TGF-β1, IL-8 levels in idiopathic pulmonary fibrosis and correlation with lung function. Methods A total of 60 cases with idiopathic pulmonary fibrosis were selected as pulmonary fibrosis group, and 60 healthy volunteers were selected as control group. Serum IL-13, TGF-β1, IL-8, arterial blood gas analy-sis and related indicators of lung function were detected. Results Serum IL-13, TGF-β1, IL-8 levels of idiopathic pul-monary fibrosis group were higher than the control group（P〈0.01）. TGF-β1, IL-8 were significantly negative correlation with FVC predicted percentage （P〈0.01）; TGF-β1, IL-13 were significantly negative correlation with FEV1 predicted percentage （P〈0.01）; TGF-β1 and PaO2 was significantly negative correlation, and TGF-β1, IL-8 were significantly positive correlation with P（A-a）O2 （P〈0.01）;IL-8 was significantly negative correlation with PaO2 and SaO2 （P〈0.01）. Conclusion Serum IL-13, TGF-β1, IL-8 levels in idiopathic pulmonary fibrosis increase significantly, and are nega-tive correlation with lung function.