麻醉方法及深度对胃癌患者围手术期细胞免疫功能的影响

Effect of anesthesia methods and depth on perioperative cellular immune function of gastric cancer patients

目的探讨麻醉方法及深度对胃癌患者围手术期细胞免疫功能的影响。方法选择60例胃癌手术患者为研究对象,随机分为静吸复合麻醉30例和单纯静脉麻醉30例,并根据患者的脑电双频指数分为深麻醉亚组和浅麻醉亚组。检测患者麻醉前、手术毕、手术后72 h外周血T细胞亚群和NK细胞数量。结果深麻醉亚组和浅麻醉亚组在手术毕时外周血CD3+、CD4+、CD4+/CD8+T细胞数量以及NK细胞数量均显著低于麻醉前和术后72 h(P<0.05)。同一种麻醉方式下深麻醉亚组手术毕CD3+、CD4+、CD4+/CD8+T细胞数量及NK细胞数量均显著高于浅麻醉亚组(P<0.05)。结论深麻醉对胃癌患者围手术期细胞免疫功能的影响较浅麻醉轻。

Objective To discuss effect of anesthesia methods and depth on perioperative cellular immune function of gastric cancer patients. Methods Sixty cases with gastric cancer treated by operation were randomly divided into in-halation anesthesia group and intravenous anesthesia group （each of 30 cases）. Two groups were divided into deep anesthesia subgroup and light anesthesia subgroups according to BIS. T lymphocyte subsets and NK cell before anes-thesia, the end of surgery, 72 h after surgery were detected. Results CD3＋, CD4＋ T cell count, CD4＋/CD8＋ and NK cell of deep anesthesia subgroup and light anesthesia subgroups at the end of surgery were lower than before anesthesia and 72 h after operation （P〈0.05）. CD3＋,CD4＋T cell count, CD4＋/CD8＋and NK cell of deep anesthesia subgroup at the end of surgery were higher than light anesthesia subgroups （P〈0.05）. Conclusion Effect of deep anesthesia on perioperative cellular immune function of gastric cancer patients is less than light anesthesia.