老年精神分裂症齐拉西酮与奥氮平治疗疗效及对血糖、血脂水平的影响

Elderly schizophrenia using ziprasidone and olanzapine therapy and its effects on blood sugar,blood lipid levels

目的比较齐拉西酮与奥氮平治疗老年精神分裂症临床疗效及对血糖、血脂代谢影响,为老年精神分裂症患者临床规范化治疗提供参考。方法按照随机数字表法将本院2011年10月~2014年2月期间98例老年精神分裂症患者分组为对照组与观察组,各49例。观察组采用齐拉西酮治疗;对照组采用奥氮平治疗。于治疗前及治疗3个月后检测两组患者血糖、血脂及体质指数水平、阴性阳性症状量表（PANSS）评分;统计两组患者临床疗效、不良反应。结果治疗后,两组患者PANSS评分较治疗前明显下降,但观察组与对照组比较,无统计学意义,P〉0.05;观察组治疗总有效者45例,总有效率为91.8%与对照组44例,89.8%比较,无统计学意义,P〉0.05。对照组治疗后血脂、空腹血糖（FPG）及BMI较治疗前明显升高,P〈0.05;而观察组治疗后血脂、FPG及BMI较治疗前比较,P〉0.05;且两组间比较,P〈0.05。观察组不良反应TESS评分为（3.10±0.19）分明显低于对照组（4.97±0.72）分,P〈0.05。结论与奥氮平相比,采用齐拉西酮治疗老年精神分裂症效果与其相当,但齐拉西酮治疗对患者血脂和血糖及体质量影响较小,同时不良反应较少,因此可作为临床治疗优选药物。

Objective By comparison and analysis of ziprasidone and olanzapine in elderly patients with schizophrenia and clinical efficacy of glucose and lipid metabolism influence,which can provide a reference for clinical standardization of treatment in elderly patients with schizophrenia. Methods According to a random number table hospital in October 2011-February 2014 period 98 cases of elderly patients with schizophrenia group was the control group and the observation group,49 cases each. Observation group ziprasidone treatment; control group with olanzapine treatment. Before treatment and after 3 months of treatment,blood glucose,blood lipid levels and body mass index groups of patients,PANSS scores; the clinical efficacy of the two groups were statistical adverse reactions. Results After treatment,patients were PANSS score was significantly decreased compared with before treatment,but the observation group and control group was not statistically significant,P 〉 0. 05; total effective observation group were 45 cases,total effective rate was 91. 8% in the control group and 44 patients,89. 8% compared with no significant difference,P 〉 0. 05. After pre-treatment control group lipids,FPG and BMI was significantly higher than before treatment,P 〈 0. 05; and lipids were observed before treatment,FPG and BMI compared with treatment comparison,P 〉 0. 05; and between the two groups,P 〈 0. 05. TESS scores were observed for adverse reactions（ 3. 10 ± 0. 19） was significantly lower than the control group points（ 4. 97 ± 0. 72） min, P 〈0. 05. Conclusion Compared with olanzapine,ziprasidone treatment of elderly patients with schizophrenia using its considerable effect,but ziprasidone therapy on serum lipids and blood sugar and body mass in patients with less impact,while fewer adverse reactions,and therefore can be used in clinical treatment preferred drugs.