精神分裂症患者甲状腺激素和性激素变化以及对药物的反应

Changes of thyroid function parameters and sex hormone levels and response to the drug in schizophrenic patients

目的分析88例流浪精神分裂症病人的内分泌功能指标,以期为临床提供一定的参考。方法选取流浪精神分裂症病人88例,作为实验组。同时选取同期我院体检的健康对照88例,作为对照组。实验组患者应用利培酮治疗,观察治疗前后两组人员的甲状腺素功能指标与性激素水平。结果 88例流浪精神分裂症病人治疗后三碘甲状腺原氨酸较之治疗前显著下降,其余指标无显著改变。经治疗后,流浪精神分裂症病人催乳素表达增多,同时男性表现为睾酮下降,女性在雌二醇与孕酮方面均表达下调。结论流浪精神分裂症病人与正常人在甲状腺功能指标与性激素方面无显著差异,但经利培酮治疗后,患者在三碘甲状腺原氨酸与睾酮、孕酮等内分泌指标发生改变。

Objective To analyze the endocrine detection index of 88 cases with homeless schizophrenia,in order to provide a reference for clinical. Methods 88 cases with schizophrenia were chosen as the experimental group. 88 cases with physical health people were chosen at the same period as control group. The experimental group were given risperidone,the thyroid function parameters and sex hormone levels of two groups before and after treatment were observed. Results The three triiodothyronine after treatment was significant lower than before treatment,the rest index showed no significant difference. After treatment,the prolactin expression of homeless schizophrenia increases,the testosterone in male were declined,while the estradiol and progesterone expression in females was declined. Conclusion The thyroid function and sex hormones between homeless schizophrenia and physical health people had no significant difference,after treatment with risperidone. The endocrine index of three triiodothyronine and testosterone and progesterone had changes.