抗抑郁药物联合心理治疗脑卒中后抑郁的对照研究

Controlled Study on Antidepressant combined with psychotherapy on Post-stroke Depression

目的探讨抗抑郁药物联合心理治疗对卒中后抑郁的影响。方法对90例脑卒中患者采用对照方法进行随访12周的前瞻性研究。结果治疗后4、8、12周研究组患者的HAMD评分均显著低于对照组(P<0.05),治疗后12周的MMSE评分显著高于对照组(P<0.05);治疗后4、8、12周研究组患者的P300潜伏期均显著短于对照组(P<0.05),治疗后2、4、8、12周P300波幅均显著长于对照组(P<0.05)。结论抗抑郁药物联合心理治疗能够显著改善卒中后患者抑郁情绪及认知功能。

Objective To study the effect of antidepressant combined with psychotherapy on PSD（ post-stroke depression）. Methods A controlled prospective design was applied in this study of 90 patients with PSD.Results The HAMD scores 4,8,12- weeks after treatment of study group were significantly lower（ P 〈 0. 05）,the MMSE score 12 weeks after treatment was significantly higher（ P 〈 0. 05）; The P300 latency 4,8,12 weeks after treatment of the study group were significantly shorter（ P 〈 0. 05）,the P300 amplitude 2,4,8,12 weeks after treatment were significantly longer than the control group（ P 〈 0. 05）. Conclusion Antidepressants combined psychological therapy can significantly improve the depression and cognitive function of stroke patients.