2型糖尿病患者血清IGF-1水平与颈动脉粥样斑块的相关性研究

The Relationship between Serum IGF-1 and carotid atheromatous plaque in T2DM patients

目的探讨2型糖尿病(T2DM)患者血清胰岛素样生长因子-1(IGF-1)水平与双侧颈动脉粥样硬化斑块的相关性。方法应用超声检测186例患者双侧颈动脉内膜-中膜厚度,根据超声检查结果将其分为:(1)A组(颈动脉粥样硬化斑块阳性的T2DM患者)96例;(2)B组(颈动脉粥样硬化斑块阴性的T2DM患者)90例。并采用免疫放射分析法检测两组患者的血清IGF-1水平。结果 A组患者的血清IGF-1水平与B组比较显著降低,差异有显著统计学意义(P<0.01);T2DM患者血清IGF-1水平与双侧颈动脉粥样斑块的程度呈显著负相关(r=0.649,P<0.01)。结论 IGF-1参与了T2DM大血管病变的发生、发展,IGF-1水平与颈动脉粥样斑块程度密切相关。

Objective To observe between serum IGF-1 levels and carotid atheromatous plaque in T2DM patients.Methods 186 T2DM patients were measured with their bilateral carotid intima media thickness（IMT）.According to the result of ultrasonic examination,patients were divided into plaque group （n =96） and no plaque group （n =90）.Plasma IGF-1 levels were measured by Immunoradiometric assay.Results IGF-1 levels were lower in plaque group than in no plaque group （P ＜ 0.01）.IGF-1 levels were negative correlation with the degree of carotid atheromatous plaque（r =0.649,P ＜ 0.01）.Conclusion IGF-1 may be involved in the occurrence and development of macroangiopathy in T2DM.