宫腔镜手术在妊娠滋养细胞肿瘤患者鉴别诊断中的应用研究

Study of hysteroscopy apply to differential diagnosis in gestational trophoblastic neoplasia patients

目的探讨宫腔镜手术对于妊娠滋养细胞肿瘤(gestational trophoblastic neoplasia,GTN)鉴别诊断的价值以及对其预后的影响。方法回顾分析本院2005年1月至2013年12月收治的怀疑GTN而行宫腔镜手术的患者的临床资料。结果 47例患者中有4例为GTN。GTN患者组与非GTN患者组之间的大部分临床资料差异无显著性。所有患者最终均获治愈。结论根据患者的临床资料难以鉴别GTN时,宫腔镜手术可协助明确诊断,对GTN患者预后无明显影响,并且可以对非GTN疾病进行有效的治疗。

Objective To determine the efficacy of hysteroscopy in differential diagnosis of suspected gestational trophoblastic neoplasia （GTN） patients, and the impact of hysteroscopy on the prognosis of GTN. Method From January 2005 to December 2013, 47 patients with a suspected diagnosis of GTN were admitted to Peking Union Medical College Hospital and underwent hysteroscopy. The clinical data and outcome of these patients were retro- spectively reviewed. Result Totally 47 eligible patients were included. Among these patients, 4 cases were diag- nosed with GTN. There was no statistical difference in the most of the clinical data between GTN patients and non- GTN patients. All the GTN patients achieved complete remission by subsequent chemotherapy or surgical therapy, and all the non-GTN patients were cured by hysteroscopy. Conclusion Hysteroscopy is an effective alternative of di- agnosis for differentiation of GTN from non-GTN diseases, when it was difficult to differentiate GTN from non-GTN diseases by clinical data. Furthermore, it can offer theraoentic treatment for non-GTN diseases.