白藜芦醇对酒精性肝损伤大鼠保护作用的研究

Study on protective effect of resveratrol on alcoholic liver injury in rats

研究白藜芦醇对大鼠血清指标及肝指数的影响,探讨白藜芦醇对肝损伤大鼠的保护作用.将72只雄性大鼠随机分为6组,空白对照组、模型对照组、低、中、高剂量组和阳性药物对照组.连续给药30 d后称取大鼠重量,取血清分别检测血清谷草转氨酶(AST)、谷丙转氨酶(ALT)和超氧化物歧化酶(SOD)、丙二醛(MDA)含量,并测定肝指数、肾指数、脾指数.结果表明,白藜芦醇能降低大鼠血清中ALT、AST、TG的水平(P<0.05),提高了SOD的含量、降低了MDA的含量(P<0.05).说明白藜芦醇具有降低大鼠ALT、AST的作用,对肝损伤大鼠具有肝保护作用.

To study the effects of resveratrol on serum indicators and hepatic index in rats, and investigate the protective effect of resveratrol on hepatic injury rats 72 male rats were randomly divided into a blank control group, model control group, resveratrol high, middle, low dosage group and positive drug control group. After 30 days of administration, rats were weighted. The serum was collected to detect glutamic - oxaloaeetic transaminase （ AST）, ala- nine aminotransferase （ ALT）, superoxide dismutase （ SOD）, malondialdehyde （MDA）, living index, kidney index and spleen index. The results showed that Resveratrol could reduce rats serum ALT, AST, TG levels （ P 〈 0.05 ） , increased the content of SOD, and reduced the content of MDA （P 〈 0.05 ）. Resveratrol has the ability decreasing rats＇ ALT and AST, and the protective effect on liver injury rats.