期刊文献+

门诊2型糖尿病患者血栓弹力图分析 被引量:4

原文传递
导出
摘要 目的 分析门诊2型糖尿病(T2DM)患者血栓弹力图的变化.方法 采用血栓弹力图仪分别对98例T2DM患者(试验组)及65例健康体检者(对照组)的凝血反应时间(R值)、凝血形成时间(K值)、凝固角(α角)、最大振幅(MA)和综合凝血指数(CI)进行检测,并分别对试验组组内的不同病程及空腹血糖水平患者的各项指标进行比较.结果 试验组血栓弹力图指标主要表现为R值、K值减小,α角、MA增大.试验组病程>5年患者(47例)R值、K值、α角、MA及CI与对照组比较差异均有统计学意义[(4.97 ±0.52) min比(6.28±1.02) min、(1.37 ±0.51) min比(2.35±0.45) min,(64.77±6.68)°比(58.34±5.31)°、(63.81±3.50) mm比(57.46±4.10) mm](P<0.01);试验组病程>5年患者R值、K值、MA、CI与病程≤5年患者(51例)比较差异有统计学意义[(4.97±0.52) min比(6.19±1.49) min、(1.37 ±0.51) min比(2.02±0.59) min、(63.81 ±3.50) mm比(60.86±4.30) mm](P< 0.05);试验组病程≤5年患者与对照组K值及MA比较差异有统计学意义[(2.02±0.59)min比(2.35±0.45) min、(60.86±4.30) mm比(57.46±4.10) mm] (P< 0.05);不同空腹血糖水平患者血栓弹力图指标比较差异均无统计学意义(P>0.05).结论 门诊T2DM患者随着病程的增加,易出现凝血、纤溶系统的改变,表现为凝血活性增强.血栓弹力图是监测T2DM患者凝血状态的一种有效手段。
出处 《中国医师进修杂志》 2015年第4期289-291,共3页 Chinese Journal of Postgraduates of Medicine
基金 海口市重点科技计划(2013-54)
  • 相关文献

参考文献6

  • 1纪宏文,马丽,高旭蓉,刘娜,张颖,王杨,马祖轩,王跃,王静,富新,熊乾,齐虹美.中国北京地区健康人群血栓弹力图参考范围的建立[J].中华医学杂志,2011,91(14):980-983. 被引量:44
  • 2Yamada T, Sato A, Nishimori T, et al. Importance of hypercoagulability over hyperglycemia for vascular complication in type 2 diabetes[Jl. Diabetes Res Clin Praet, 2000,49( 1 ) :23-31.
  • 3Tantry US, Bliden KP, Gurbel PA. Overestimation of platelet aspirin resistance detection by thrombelastograph platelet mapping and validation by conventional aggregometry using arachidonie acid stimulation [ J ]. J Am Coil Cardiol, 2005,46 (9) : 1705-1709.
  • 4Stein SC, Chen XH, Sinosn GP, et al. Intravascular coagulation: a major secondary insult in nonfatal traumatic brain injury [J]. J Neurosurg, 2002,97(6) : 1373-1377.
  • 5Harris MI,Klein R,Welborn TA,et al. Onset of NIDDM occurs at least 4-7 yr before clinical diagnosis [J]. Diabetes Care, 1992,15 (7):815-819.
  • 6胡仁健,胡逢来.2型糖尿病患者凝血状态分析[J].中国现代医药杂志,2007,9(9):54-56. 被引量:3

二级参考文献14

  • 1[1]Yamada T,Sato A,Nishimori T,et al.Importance of hypercoagulability over hyperglycemia for vascular complication in type 2 diabetes[J].Diabetes Res Clin Pract,2000,49(1):23-31
  • 2[2]Adelstein S,Garnpets ED,Joffe BI,et al.Haemostatic factors in black and white diabetics[J].S Aft Med J,1999,55:325-328
  • 3[3]Carr ME.Diabetes mellitus:A hypercoagulable state[J].Journal of Diabetes& its complications,2001,15 (1):44-54
  • 4[5]Chan P,Pan WH.Coagulation activation in type 2 diabetes mellitus:the higher coronary risk of female diabetic patients[J].Diabet Med,1995,12(6):504-507
  • 5[6]Vambergue A,Rugeri L,Gaveriaux V,et al.Factor,tissue factor pathway inhibitor,and monocyte tissue factor in diabetic mellitus:influence of type of diabetes,obesity index,and age.Thromb Res,2001,101(6):367-375
  • 6[7]Kessler L,Azimzadeh A,Wiesel,et al.Effect of insulin on von Wille brand factor release in normal and diabetic subjects:in vivo and invitro stedies.Horm Metab Res,2001,33(10):674-680
  • 7Scarpelini SG, Rhind B, Naseimento H, et al. Normal range values for thromboelastography in healthy adult volunteers. Braz J Med Biol Res, 2009, 12:1210-1217.
  • 8Kaufmann CR, Dwyer KM, Crews JD, et al. Usefulness of thromboelastography in assessment of trauma patient coagulation. J Trauma, 1997, 42:716-720.
  • 9Wang SC, Shieh JF, Chang KY, et al. Thromboelastography- guided transfusion decreases intraoperative blood transfusion during orthotopic liver transplantation : randomized clinical trial. Transplant Proc,2010, 42:2590-2593.
  • 10Reikvam H, Steien E, Hauge B, et al. Thromboelastography. Transfus Apher Sci ,2009, 40 : 119-123.

共引文献45

同被引文献41

引证文献4

二级引证文献23

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部