晚期结肠癌患者应用香菇多糖与化疗治疗的临床效果观察

Clinical effect observation of lentinan and chemotherapy in the treatment of patients with advance colon cancer

目的观察和评价香菇多糖联合XELOX化疗方案治疗晚期结肠癌的效果。方法 48例晚期结肠癌患者随机分为治疗组和对照组,每组24例。治疗组在采用XELOX方案化疗的同时给予香菇多糖,对照组仅采用XELOX方案化疗。随访比较两组患者的无进展生存期和总生存期。结果两组均未发生治疗相关性死亡。两组不良反应以血液学毒性、消化道反应、神经毒性为主。治疗组KPS评分有效率为83.33%(20/24),而对照组有效率为41.67%(10/24),差异具有统计学意义(P<0.05),治疗组和对照组的临床近期有效率分别为75.00%(18/24)和62.50%(15/24),差异具有统计意义(P<0.05)。结论香菇多糖联合XELOX方案化疗可增强患者的细胞免疫功能,提高化疗疗效,减轻化疗所致的毒副作用,明显改善患者治疗后生活质量,值得临床推广应用。

Objective To observe and evaluate the effect of lentinan combined with XELOX chemotherapy regimen in the treatment of advanced colon cancer. Methods A total of 48 patients with advanced colon cancer were randomly divided into treatment group and control group, with 24 cases in each group. The treatment group received XELOX chemotherapy regimen and lentinan at the same time. The control group was treated by XELOX chemotherapy regimen alone. Follow-up was taken to compare progression free survival and overall survival between the two groups. Results No treatment related death case was found in both groups. The main adverse reactions in the two groups included hematological toxicity, gastrointestinal reaction, and neurovirulence. The effective rate of KPS score in the treatment group was 83.33%（20/24）, while the effective rate in the control group was 41.67%（10/24）. The difference had statistical significance（P〈0.05）. The short-term clinical effective rates of the treatment group and control group were respectively 75.00%（18/24） and 62.50%（15/24）. The difference had statistical significance（P〈0.05）. Conclusion Combination of lentinan and XELOX chemotherapy regimen can improve cellular immune function and curative effect of chemotherapy, and reduce toxic and side effects in chemotherapy. It can improve patients＇ life quality after treatment, and is worth clinical promotion and application.