肝硬化患者的凝血四项检查临床分析

Clinical analysis of four blood coagulation items examination in liver cirrhosis patients

目的探讨肝硬化患者凝血系统发生异常改变,对其进行血浆凝血四项检测的临床意义。方法检测40例肝硬化患者(肝硬化组)和40例健康对照者(对照组)血浆活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)以及纤维蛋白原(FIB)的含量,并进行比对和分析。结果肝硬化组FIB含量较对照组明显减少(P<0.01),肝硬化组PT、APTT、TT较对照组明显延长(P<0.01)。结论肝硬化患者存在明显的凝血功能障碍,容易发生广泛性出血等并发症,对其进行凝血功能检测,对预防肝硬化患者出血倾向等并发症有一定的临床意义。

Objective To explore the clinical significance of four blood coagulation itmes examination for abnormal changes in coagulation system in liver cirrhosis patients. Methods Detections were made on contents of plasma activated partial thromboplastin time（APTT）, prothrombin time（PT）, thrombin time（TT）, and fibrinogen（FIB） in 40 liver cirrhosis patients（liver cirrhosis group） and 40 healthy control people（control group）. The results were compared and analyzed. Results The liver cirrhosis group had lower FIB content than the control group（P0.01）, and its PT, APTT, and TT were all extended than the control group（P0.01）. Conclusion Obvious coagulation disorders occurs in liver cirrhosis patients, and it is easy for them to have complications as extensive bleeding. Detection of coagulation function provides clinical significance for prevention of complications of hemorrhagic tendency in liver cirrhosis patients.