固肺镇咳中药及其拆方对支气管哮喘患者肺功能及Th17/Treg平衡的调节作用

Effects of consolidating lung suppressing cough formula and its modified formula on lung function and its regulation effects for Th17/Treg balance in patients with bronchial asthma

目的:探讨固肺镇咳中药及其拆方治疗对支气管哮喘患者肺功能及Th17/Treg平衡的调节作用,为临床诊治支气管哮喘提供理论依据。方法:纳入本院支气管哮喘的患者200例,随机分为4组,其中对照组50例,给予抗生素、止咳、化痰、平喘等常规的治疗;固肺镇咳全方组50例,拆方I组50例、拆方II组50例,在常规的治疗的基础上加用中药全方及拆方治疗,1剂/d,常规水煎服,每次约200mL,连续服用12周。于治疗的前后分别测定患者的肺功能和酶联免疫吸附法检测白介素-17(IL-17)和白介素-10(IL-10)的水平。结果 :固肺镇咳全方组和拆方组与治疗前相比肺功能的各项指标1秒用力呼气的容积(FEV1)、用力肺活量(FVC)、呼气的峰值流速(PEF)均明显增加,差异具有统计学意义(P<0.05);对照组相比观察组的IL-17水平明显下降,而IL-10水平明显升高,差异具有统计学意义(P<0.05);相关分析结果表明IL-17和IL-10呈负相关,IL-10/IL-17明显增高,其组间差异具有统计学意义(P<0.05)。结论:固肺镇咳中药及其拆方应用治疗支气管哮喘不仅可以改善患者的肺功能,而且还在一定程度上调节了Th17/Treg平衡。

Objective： To investigate Effects of consolidating lung suppressing cough formula and its modified formula on lung function and its regulation effects for Thl7 / Treg balance in patients with bronchial asthma. Methods.. 200 patients di- agnosed with bronchial asthma were randomly divided into four groups, including control group （n= 50 patients）, consolida- ting lung suppressing cough formula （n= 50 cases）, modified formula 1 （n= 50 cases）, modified formula 2 （n=50 cases）. The control group received conventional treatment of antibiotics, suppressing cough, resolving sputum and relieving asthma, etc. ; the other three groups were given consolidating lung suppressing cough formula and its modified formula based on basic conventional treatment, 1 decoction/d, 200 mL/time for a consecutive 12 weeks. Lung function were measured by enzyme- linked immunosorbent assay, levels of IL-17 and IL-10 in the before and after treatment were also detected. Results.. Compared with parameters before treatment, indicators of lung function including FEV1, FVC, PEF were significantly increased （P〈0.05）. IL-17 levels of the observation group were significantly decreased, while II-10 were increased compared with that of con- trol group. The results show that IL17 and IL-10 were negatively correlated, IL-10/IL-17 was significantly higher, significant differences among these groups were observed （P〈0.05）. Oonclusion： Consolidating lung suppressing cough formula can im- prove lung function and regulate Th17 / Treg balance in patients with bronchial asthma.