拉贝洛尔对早发型重度子痫前期患者凝血及纤溶指标的影响

Effects of labetalol intervention on the indexes of coagulation and fibrinolysis in patients with early onset severe preeclampsia

目的:探讨拉贝洛尔对早发型重度子痫前期患者凝血及纤溶指标的影响。方法:114例早发型重度子痫前期患者,随机分为对照组和观察组,各57例。对照组给予常规治疗。观察组在常规治疗基础上,加用拉贝洛尔治疗。结果:观察组治疗后收缩压、舒张压都低于对照组,差异均有统计学意义(P<0.01);观察组治疗后24h尿量(24hUV)高于对照组,24h尿蛋白定量(24hUP)低于对照组,差异均具有统计学意义(P<0.01);观察组治疗后凝血酶原时间(PT)、活化部分凝血酶活酶时间(APTT)都高于对照组,纤维蛋白原(Fg)、D-二聚体(DD)都低于对照组,差异均有统计学意义(P<0.01)。观察组Apgar评分高于对照组,差异具有统计学意义(P<0.01);观察组新生儿窒息和早产儿发生率少于对照组,差异具有统计学意义(P<0.05)。结论:拉贝洛尔治疗早发型重度子痫前期患者疗效确切,可有效缓解早发型重度子痫前期患者血压和蛋白尿等症状和体征,改善血液流变性,增强纤溶活性,有利于母婴安全。

Objective： To investigate the effects of labetalol intervention on the indexes of coagulation and fibrinolysis in patients with early onset severe preeclampsia. Methods：A total of 114 early onset severe preeclampsia patients were randomly divided into control group and observation group with 57 cases in each. The control group was given routine treatment, and the observation group was given labetalol based on routine treatment. Results： After the treatment, systolic blood pressure, diastolic blood pressure of the observation group was significant lower than those of the control group （P〈0.01）. After treat- ment, 24 h UV of the observation group was higher than those in the control group （P〈0.01）, but 24 hUP of the observation group was lower than that of the control group （P〈0.01）. After treatment, PT, APTT of the observation group were higher than those in the control group （P〈0.01）. After treatment, Fg, DD of the observation group were lower than those in the control group. Apgar score of the observation group was significant higher than those in the control group （P〈 0.01）. Neonatal asphyxia and the incidence of premature birth of the observation group were significant less than that in the control group（P〈0. 05）. Oonclusion..Labetalol shows good effects on early onset of severe preeclampsia, it can effectively alleviate the patients blood pressure and proteinuria symptoms and signs, improve blood rheology, enhance the fibrinolytic activity, and it is conducive to the safety of mother and infant.