艾司西酞普兰联合心理干预对卒中后抑郁的影响

Effect of escitalopram combined with mental intervention on post-stroke depression

目的:探讨艾司西酞普兰联合心理干预对卒中后抑郁(PSD)的影响。方法:选取在本院内科住院的PSD患者128例,随机纳入干预组(66例)和对照组(62例)。对照组采用常规治疗,干预组在常规治疗基础上加用艾司西酞普兰联合心理干预治疗。比较两组第4、8周抑郁自评量表(SDS)、汉密尔顿抑郁量表(HAMD)、日常生活能力量表-巴氏指数(BI)情况。结果:干预组第4周、第8周的SDS评分、HAMD评分及ADL评分均低于对照组,差异均有统计学意义(P<0.01)。结论:艾司西酞普兰联合心理干预能改善脑卒中患者的抑郁状态,改善患者的生活质量与预后,值得临床推广应用。

Objective： To observe the effects of Escitalopram combining with mental intervention on post-stroke depres sion. Methods： A total of 128 patients with PSD after cerebral stroke were randomly divided into study groups （n= 66） and control groups （n= 62）. The control group accepted conventional therapy. And the study group accepted Escitalopram and mental intervention therapy. Clinical effects were evaluated at 4th and 8th week after treatment with Self-rating Depression scale（SDS）, Hamilton Depression Scale （HAMD） and Activity of Daily Living Scale（ADL）-Barthel Index（BI）. Results.. Compared with the control group, the SDS, HAMD and ADL scores were lower at the end of the 4th and 8th week in the study group, and were also significant lower than that of the control group （P〈0.01）. Conclusion.. Escitalopram combining with mental intervention has reliable effects on symptoms of depression after stoke, it can improve the patient＇s quality of life and prognosis, so it has clinical application value.