青浦区公立医疗机构药品不良反应报告回顾性分析

Retrospective analysis of 1510 cases of adverse drug reactions reported by public medical institutions in Qingpu District

目的:了解上海市青浦区药品不良反应(ADR)发生的特点及一般规律,为临床合理用药提供参考。方法:汇总2012-2013年我区14家公立医疗机构上报的1 510例ADR报告,按患者性别、年龄、给药途径、药品种类、累及器官或系统及临床表现等进行统计、分析。结果:ADR发生率在60岁以上患者中居首位,占34.04%,女性患者较男性多,分别占59.30%和40.70%;引发ADR的途径以静脉滴注给药为主,占80.70%,其中由抗菌药物引发的ADR最多,占74.04%;ADR累及器官或系统以皮肤及其附件损害最常见,占48.77%。结论:通过分析统计,应重视ADR的监测工作,尤其要重视合理使用抗菌药物及关注ADR的易发人群,以减少ADR的发生。

Objective： To investigate the characteristics and regular pattern of adverse drug reactions （ADR） occurred in the 14 public medical institutions of Qingpu District so as to provide a reference for the rational medication. Methods： One thousand five hundred and ten cases of ADR events summarized during 2012-2013 were retrospectively analyzed in terms of the gender and age of patients, the route of administration, drug variety, ADR-involved organs or systems and clinical manifestations. Results： The incidence of ADR ranked first in patients over 60 years old, accounting for 34.04% and was higher in the female patients than in the male ones （59.30% vs 40.70%）. The main way to trigger ADR was intravenous administration, accounting for 80.70%, in which the ADR induced by antibacterial agents was the most common, accounting for 74.04%. ADR-involved organs or systems were the most common in skin and its appendages, accounting for 48.77%. Conclusion： Great attention should be paid to the monitoring of ADR, especially to the rational use of antibiotics and the ADR prone population so as to reduce the occurrence of ADR.