氨溴索联合酚妥拉明辅助治疗小儿重症肺炎疗效观察

Effect of ambroxol hydrochloride combined with phentolamine in adjuvant treatment of severe pneumonia in children

目的：观察盐酸氨溴索注射液联合酚妥拉明注射液辅助治疗小儿重症肺炎的疗效，为临床治疗方案的制定提供参考。方法选取重症肺炎患儿93例，按照随机数字表法分为A组、B组和C组各31例。A组采用常规治疗措施进行治疗，B组在A组治疗方案的基础上，加用盐酸氨溴索注射液静脉泵入，C组在B组治疗方案的基础上，加用酚妥拉明注射液静脉泵入。治疗7d后比较三组患儿临床症状、体征消失情况及其住院天数，比较三组患儿的临床疗效并观察其不良反应。结果 C组退热时间为（1．98±1．25）d，心力衰竭消失时间为（1．71±0．92）d，咳嗽消失时间为（2．90±1．08）d，啰音消失时间为（6．22±1．13）d，住院时间为（6．42±1．57）d，均显著短于A组（t＝4．55、4．72、4．38、4．59、5．12，均P＜0．05）和B组（t＝3．98、3．76、4．12、4．08、4．14，均P＜0．05）；B组患儿的退热时间、心力衰竭消失时间、咳嗽消失时间、啰音消失时间均显著短于A组（t＝3．97、4．01、3．88、3．56，均 P＜0．05）；C 组显效率为41．94％，有效率为54．84％，总有效率为96.77％，C组总有效率显著高于A组和B组（χ^2＝10．33、5．16，均P＜0．05）；三组患儿治疗过程中均未出现严重的不良反应。结论盐酸氨溴索注射液联合酚妥拉明注射液辅助治疗小儿重症肺炎可更快控制小儿重症肺炎的病情，提高小儿重症肺炎的临床疗效，且不良反应少，值得推广应用。

Objective To observe the effect of ambroxol hydrochloride combined with phentolamine in adju-vant treatment of severe pneumonia in children.Methods According to the digital table,93 children with severe pneumonia were selected and randomly divided into A group,B group and C group with 31 cases in each group.Agroup with conventional measures for treatment of severe pneumonia in children for treatment,B group based on treatment scheme of A group,with ambroxol hydrochloride injection intravenous infusion in group B,group C foundationtreatment scheme,combined with phentolamine intravenous infusion.After 7d treatment in three groups were comparedthe clinical symptoms,signs and hospitalization days disappear,at the same time,the clinical effect between threegroups of children and to observe the adverse reaction.Results In C group,the cooling time for（1.98 ±1.25）d,heart failure free period of （1.71 ±0.92）d,cough disappeared time of （2.90 ±1.08）d,rales disappearing for（6.22 ±1.13）d,the time of hospitalization for （6.42 ±1.57）d,were significantly lower than those of A group（t =4.55,4.72,4.38,4.59,5.12,all P 〈0.05）and B group（t =3.98,3.76,4.12,4.08,4.14,all P 〈0.05）,B groupof children with heart failure disappeared,antipyretic,cough disappeared,rales disappearing time was significantlylower than that in A group（t =3.97,4.01,3.88,3.56,all P 〈0.05）;After treatment,in C group,the markedly effective rate was 41.94%,effective rate was 54.84%,total effective rate was 96.77%,which were significantly higherthan those in A group and B group（χ^2 =10.33,5.165,all P 〈0.05）;The three groups of children in the course oftreatment were not serious adverse reactions.Conclusion Ambroxol hydrochloride injection combined with phentolamine injection can quickly control of children with severe pneumonia disease,improve the clinical efficacy in children with severe pneumonia,and less adverse reactions,which is worthy of popularization and application.