氟哌利多加哌替啶联合宫旁阻滞麻醉用于人工流产术的疗效观察

The anesthesia effect in patients undergoing artificial abortion treated with droperidol and pethidine hydro-chloride in combination with paracervical block

目的：研究氟哌利多、盐酸哌替啶联合利多卡因宫旁阻滞麻醉用于人工流产术的疗效。方法选取386例宫内妊娠6～8周患者，采用数字表法将其随机分为两组。研究组193例患者，给予氟哌利多、盐酸哌替啶联合利多卡因宫旁阻滞麻醉；对照组193例患者仅给予同等剂量的氟哌利多、盐酸哌替啶麻醉。比较两组患者的镇痛效果、血流动力学指标、宫口开放情况及副作用的差别。结果研究组镇痛总有效率为91．7％，高于对照组的72．0％（χ^2＝25．198，P＜0．01）。人工流产术中，研究组血流动力学指标较对照组更为稳定（t＝4．545、3．674，均P＜0．01）。研究组孕妇宫口完全松弛者102例，部分松弛者69例，宫口紧者22例；对照组依次为69例、60例及64例。经比较，两组患者宫口松弛程度的差异有统计学意义（Z＝4.643， P＜0．01）。研究组的人流综合征发生率明显低于对照组（χ^2＝7．580，P＝0．006）。结论氟哌利多加盐酸哌替啶联合宫旁阻滞麻醉用于人工流产术具有良好的疗效，安全性高，值得在基层医院推广。

Objective To analyze the anesthesia effect of droperidol and pethidine hydrochloride in combina-tion with paracervical block in artificial abortion.Methods 386 patients undergoing artificial abortion were admitted. They were randomly divided into the two groups.The study group（193 cases）was treated with droperidol and pethi-dine hydrochloride in combination with paracervical block,while the control group （193 cases）was treated with droperidol and pethidine hydrochloride only.The analgesic effect,hemodynamics,cervix relaxation and side effects between the two groups were compared.Results The analgesic effect of the study group was 9 1 .7%,which was much higher than 72.0% of the control group（χ^2 =25.198,P〈0.01）,and there were significant differences between the two groups in hemodynamics（t=4.545,3.674,all P〈0.01）.The total cervix relaxation were 102 cases,and partly cervix relaxation were 69 cases in the study group,which were significantly higher than that of the control group （69 cases,60 cases,respectively;Z=4.643,P〈0.01）.There was no difference between side effects except for abor-tion syndrome（χ^2 =7.580,P=0.006）.Conclusion Droperidol and pethidine hydrochloride in combination with paracervical block have an excellent effect on artificial abortion.