中西医结合治疗精神分裂症的疗效观察

Effects of combination of traditional Chinese and Western medicine in treatment of schizophrenia

目的：研究中西医结合疗法治疗精神分裂症的临床疗效及安全性。方法选择精神分裂症患者130例，采用随机数字表法分为观察组和对照组，各65例。对照组予以奋乃静等西药治疗，观察组在对照组治疗基础上加用解郁开窍丸治疗。比较两组临床疗效、PANSS评分及药物不良反应发生情况。结果观察组治疗总有效率为96．92％，明显高于对照组的72．31％；观察组治疗后PANSS评分为（42．68±6．11）分，对照组为（55．12±6．45）分，两组PANSS评分均较治疗前明显降低，观察组治疗后PANSS评分明显低于对照组，差异有统计学意义（t＝6．61，P＜0．05）；观察组不良反应发生率为10．77％，明显低于对照组的58．46％，差异有统计学意义（χ^2＝32．66，P＜0．05）。结论解郁开窍丸联合西药用于治疗精神分裂症，可显著提高疾病治疗的临床疗效，降低药物不良反应发生率。

Objective To evaluate the clinical efficacy and safety of combined therapy of Chinese and West-ern medicine in the treatment of schizophrenia.Methods According to the digital table,130 patients with schizophre-nia were randomly divided into the observation group and control group,with 65 cases in each group.The control group was treated with perphenazine and other Western medicine treatment,the observation group was treated based on the control group with Jieyu Kaiqiao pill added,The clinical curative effect,PANSS score and adverse drug reaction of both groups were compared.Results In the observation group,the total effective rate was 96.92%,significantly high-er than that of the control group （72.31%）;After treatment,PANSS score of observation group was （42.68 ±6.11）, while it was （55.12 ±6.45）in control group.The PANSS scores of both groups were significantly lower than that before treatment,PANSS score of observation group was significantly lower than that of the control group,there was significant difference between groups（t=6.61,P〈0.05）;the incidence of adverse reaction of the observation group was 10.77%,significantly lower than the control group （58.46%）;the difference was statistically significant （χ^2 =32.66,P〈0.05）.Conclusion Jieyu Kaiqiao pill combined with Western medicine for the treatment of schizophre-nia can significantly improve the clinical efficacy,reduce the incidence of adverse drug reactions.