砷中毒患者血浆中纤维蛋白原检测的临床意义

Clincial significance of fibrinogen in the plasma detection among arsenic poisoning patients

目的探讨纤维蛋白原(FBG)在砷中毒患者血浆检测中的临床意义。方法收集湖南省职业病防治院从2012年7月—2013年12月确诊为砷中毒的患者84例(砷中毒组)和健康检查正常者84例(对照组)抽取静脉血分别进行FBG、凝血酶原时间(PT)、白蛋白(ALB)等3项测定,并对所有结果进行统计分析。结果砷中毒组FBG、ALB检测结果均明显低于对照组,差异有统计学意义(P<0.01),PT检测结果差异并无统计学意义。且砷中毒治疗后FBG含量明显高于治疗前,差异有统计学意义(P<0.01)。结论 FBG检测对于砷中毒的诊疗具有较大价值,可以作为一种较为理想的辅助诊断砷中毒的指标。

[Objective] To investigate the clinical significance of fibrinogen in the plasma detection among arsenic poisoning patients. [Methods] 84 patients with diagnosis of arsenic poisoning in Hunan prevention and treatment center for octupational disease from July 2012 to December 2013 were collected as experimental group, and 84 cases of normal health examination were collected as control group. Their venous blood was drawn for FBG, PT and ALB measurement, and the results were analyzed. [Results] The FBG and ALB results of arsenic poisoning group were significantly lower than that of control group , the difference was statistically significant （P〈0.01）, the difference of PT results was not statistically significant. And after arsenic poisoning treatment, FBG contents were significantly higher than that before treatment, the difference was statistically significant （P〈0.01） . [Conclusion] FBG testing has a larger value for the diagnosis and treatment of arsenic poisoning , and can be used as an ideal auxiliary diagnostic index.