温中运脾补肾法治疗2型糖尿病临床研究

Therapeutic Effect of Middle-warming and Spleen-strengthening and Kidney-tonifying Therapy for Type 2 Diabetes Mellitus

目的观察温中运脾补肾法中药对2型糖尿病患者血糖、血脂、胰岛素敏感性、体重指数方面的作用。方法将105例2型糖尿病患者按2:1比例随机分为中药组70例和对照组(二甲双胍组)35例,疗程均为8周。比较两组血糖、糖化血红蛋白、血脂、空腹胰岛素、胰岛素敏感指数、体重指数的变化。结果中药组治疗后胰岛素敏感性和高密度脂蛋白胆固醇提高(P<0.05);空腹血糖、餐后2h血糖、糖化血红蛋白、甘油三酯、高空腹胰岛素、体重指数降低(P<0.05)。与对照组比较,降低空腹血糖、餐后2h血糖、糖化血红蛋白的作用相当(P>0.05),而降低甘油三酯、高空腹胰岛素、体重指数,提高胰岛素敏感性和高密度脂蛋白胆固醇的疗效,中药组则优于对照组(P<0.05)。结论温中运脾补肾法中药治疗2型糖尿病有较好疗效。

Objective To observe the effect of middle-wanning and spleen-strengthening and kidney-tonifying therapy on lowering glucose, regulating blood lipid, increasing insulin sensitivity and decreasing body mass index in type 2 diabetes mellitus patients. Methods 105 cases of patients with type 2 diabetes, according to the proportion of 2：1 were randomly divided into the Chinese medicine group of 70 cases and the control group （meffonnin group） 35 cases. The course of treatment lasted 8 weeks. Blood glucose, glycosylated hemoglobin, blood lipids, fasting insulin, insulin sensitivity index and body mass index were observed in the two groups before and after intervention. Results After treatment insulin sensitivity and high density lipoprotein cholesterol were improved in the Chinese medicine group （P〈0.05）. Blood glucose, glycosylated hemoglobin, triglycerides, high fasting insulin and body mass index decreased in the Chinese medicine group （P〈0.05）. Compared with the control group, the effect on lowering the fasting blood glucose, 2-hour postprandial glucose and glycosylated hemoglobin were equivalent （P〉0.05）. While the effect on lowering triglycerides, high fasting insulin and body mass index as well as improving the efficacy of insulin sensitivity and high density lipoprotein cholesterol, the Chinese medicine group is better than the control group （P〈0.05）. Conclusion Middle-wanning and spleen-strengthening and kidney-tonifying therapy exerts better curative effect for T2DM patients.