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外周5-羟色胺在胰岛素抵抗中的作用研究进展 被引量：2

Research Progress in the Role of Peripheral 5- hydroxytryptamine in Insulin Resistance
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摘要 5-羟色胺(5-HT)作为一种神经递质在中枢神经系统中具有重要的作用,同时在外周组织系统中5-HT也发挥多种重要的生物功能,如广泛参与机体的糖脂代谢、肝再生、胃肠运动等。综述外周5-HT诱导胰岛素抵抗的作用机制研究新进展,重点介绍5-HT对胰岛素信号转导、糖脂代谢等方面的影响。 5-hydroxytryptamine （5-HT） is a neurotransmitter with important functions in the central nervous system. Besides, it is implicated in a vast array of physiological activities in peripheral tissues including glucose and lipid metabolism, liver regeneration, gastrointestinal motility, etc. The latest research achievements on the role of peripheral 5-HT in insulin resistance （IR） were reviewed in this article, which mainly focused on the involvement of 5-HT on insulin signal transduction, glucose and lipid metabolism during IR status.
作者 李涛 傅继华 王天莹
机构地区 中国药科大学药学院生理教研室 中国药科大学药学院
出处 《药学进展》 CAS 2015年第2期113-118,共6页 Progress in Pharmaceutical Sciences
基金 中国药科大学大学生创新训练计划项目(No.J1030830)
关键词 5-羟色胺 胰岛素抵抗 信号转导 糖脂代谢 5-hydroxytryptamine insulin resistance signal transduction glucose and lipid metabolism
分类号 R587 [医药卫生—内分泌] R966 [医药卫生—药理学]
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参考文献35

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共引文献72

同被引文献9

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药学进展
2015年 第2期

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