莫扎特K.448对颞叶癫痫模型鼠高频脑电活性的影响

Effects of Mozart K. 448 on High-Frequency EEG Activities in Temporal Lobe Epilepsy Model Mice

选用C57BL/6小鼠,随机分为两组.实验组小鼠通过匹罗卡品（PILO）腹腔注射,诱发癫痫持续状态（SE）;对照组给予等容量生理盐水.SE后4周测试小鼠听力,SE后6~7周播放莫扎特K.448,探究莫扎特K.448对颞叶癫痫模型鼠自发发作期高频脑电（EEG）活性的影响.数据显示,PILO注射未明显影响小鼠的听力,给予莫扎特K.448使对照组与SE模型鼠在55~145 Hz区间的功率谱显著升高.结果表明,短时期给予莫扎特K.448音乐治疗能导致小鼠EEG高频活性增强.

C57BIJ6 mice were randomly divided into two groups. The mice in experimental group were given intra- peritoneal injection of pilocarpine （PILO） to evoke status epilepticus （SE） , and the mice in control group were given saline with the same volume. Auditory capacities of mice were tested at 4 weeks after the onset of SE, and to investi- gate effects of Mozart K. 448 on high frequency electroencephalogram （EEG） activities at spontaneous recurrent seizure state in temporal lobe epilepsy model mice. Mozart K. 448 was played at 6 to 7 weeks after the onset of SE. According to experimental data, PILO-injected not affect auditory capacities of mice significantly and Mozart K. 448 therapy en- hanced EEG activity at frequencies between 55 Hz to 145 Hz both in control and SE model mice . The results showed that short-term playing of Mozart K. 448 enhanced high frequency EEG activities.