HbA1c、Hs-CRP在GDM诊断的早期预测价值

Early clinical predictive values of Hb Alc and Hs-CRP in the diagnosis of gestational diabetes mellitus

目的研究糖化血红蛋白(H b A 1 c)联合超敏C反应蛋白(H s-C P R)在妊娠期糖尿病(G D M)诊断的早期临床预测价值。方法对照组1 1 0例,G D M组7 2例,检测不同孕周的H b A 1 c、H s-C P R血清水平。结果两组H b A 1 c、H s-C P R血清水平不同孕周组内无差异,组间经方差分析差异均有统计学意义(P<0.0 5);两组H b A 1 c、H s-C P R的异常率差异有统计学意义(P<0.0 5);联合检测的特异性和阳性预测值明显高于两者单独检测结果(P<0.0 5)。结论 H b A 1 c联合H s-C P R的检测对妊娠糖尿病早期诊断有重要的临床预测意义。

Objective To study the early clinical predictive value of the glycosylated hemoglobin （HbA l c ） and high-sensitivity C-reactive protein（Hs-CPR） in the diagnosis of gestational diabetes mellitus. Meth- ods Detection of the serum levels of HbAlc and Hs-CPR in different gestational age for 110 cases of the control group and 72 cases of GDM group. Results It was no difference on the serum levels of HbAlc and Hs-CPR within the groups in different gestational age; Analysis of variance between groups were statistically significant differences （P〈0.05）;abnormal rate differences of HbA l c, Hs-CPR were statistically significant （P〈0.05） between groups;specificity and positive predictive value of combined detection significantly higher than the results of two separate test （P〈0.05）. Conclusions It has important clinical prognostic significance of HbA 1 c joint Hs-CPR testing in early diagnosis of gestational diabetes.